DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32819 and TEKT5

DIOPT Version :9

Sequence 1:	NP_728444.1	Gene:	CG32819 / 318227	FlyBaseID:	FBgn0052819	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_653275.1	Gene:	TEKT5 / 146279	HGNCID:	26554	Length:	485	Species:	Homo sapiens

Alignment Length:	490	Identity:	172/490 - (35%)
Similarity:	283/490 - (57%)	Gaps:	35/490 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 MESYPWSQAGA-PPCMEPVMGPSIPPRVGAAYETPTKHPWRPAMAYELIQVKHMPEQPVTNQLTK 169
            :.|.|..||.. ..|.:|...|      |..|    .:.|||::.|::..|:..|::. |:.|..
Human    21 LTSLPAVQAPVIQECYQPYYLP------GYRY----LNSWRPSLFYKIANVQTCPDES-TSTLRP 74

  Fly   170 QCFLPKGMKTDGMIFPNLVTGFDRNPQHAARAALYTRYTSNEWYNNNMTKYSESNMNRNLSERMR 234
            ...||                       ..|:||::||:.::|..:|..:...:..:|..:.|:.
Human    75 PTILP-----------------------TLRSALFSRYSPHDWDQSNQLQVRGAEASRLWASRLT 116

  Fly   235 NDAVRLMRETDEKATSGQRDAGRRLGERITDLTFWRNELNAELEKLIAEMSDINELQRQCGKALL 299
            :|::||:::.|:.....|....|.||:|::|:.||::||:.||::|:.|..::..::|:...|..
Human   117 DDSMRLLQDKDQLTHQMQEGTCRNLGQRLSDIGFWKSELSYELDRLLTENQNLETVKRRLECAAN 181

  Fly   300 DLEIPLHIAQECLFHRESRQGTEKVHDIVEKALLVEINNLRNSRDRLGGLHEKISKQALDCRGAQ 364
            ::..||.:|.|||:|||.|.|.:.|||.|||.|:.|::.|:..::::..|.::|..|..|.|.||
Human   182 EVNCPLQVALECLYHREKRIGIDLVHDNVEKNLIREVDLLKCCQEQMRKLAQRIDIQMRDNRDAQ 246

  Fly   365 HLLEDDVSHKESSLGIDSMCHQLNNHSRGITYYGGIEKFDPSVSTQESWAQASSEHVRRSQAERA 429
            |:||.|:..|.|:..||..|..|.|.|..|:::.|:||.|.::|..|:||:.|:::::.||..||
Human   247 HVLERDLEDKSSAQCIDEKCFNLRNTSDCISFFHGMEKIDGTISVPETWAKFSNDNIKHSQNMRA 311

  Fly   430 KLSQLRSDAQSVVNSVATTVWDFWSNTNNAFDRRSQEMAEAKNRVQLHLQKVQQELFDMEKHLFL 494
            ...|||.:|:.:..:::..:|..:::||.||:.|..|:.:.||::|..|.|..||:|..|..:.|
Human   312 NSIQLREEAEHLFETLSDQMWRQFTDTNLAFNARISEVTDVKNKLQTQLAKTLQEIFQAENTIML 376

  Fly   495 LQKAIQDKSGPLKVAQTRLEARSHREGVELCKDHAQDRLVQEVQDIQGAVETLHHKLMEAEATHQ 559
            |:::|..|.|||||||||||.|:.|..:|||:|..|.:||.||..|...::||..:|.|.:.|.|
Human   377 LERSIMAKEGPLKVAQTRLECRTRRPNMELCRDIPQLKLVNEVFTIDDTLQTLKLRLRETQDTLQ 441

  Fly   560 GLLKTRCTLEVDLRNKVNALFIDREKCMSLRRSFP 594
            .|:.|:|.||.:|..|.|.|.||:||||.:|::||
Human   442 LLVMTKCRLEHELAIKANTLCIDKEKCMGMRKTFP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32819	NP_728444.1	Tektin	212..591	CDD:281184	145/378 (38%)
TEKT5	NP_653275.1	Tektin	94..473	CDD:308655	145/378 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158895
Domainoid	1	1.000	329	1.000	Domainoid score	I1158
eggNOG	1	0.900	-	-		E1_KOG2685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2349
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59762
OrthoDB	1	1.010	-	-		D264325at33208
OrthoFinder	1	1.000	-	-		FOG0000711
OrthoInspector	1	1.000	-	-		otm41082
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19960
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3619
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870