DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32808 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_726740.1	Gene:	CG32808 / 318221	FlyBaseID:	FBgn0052808	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	248	Identity:	92/248 - (37%)
Similarity:	135/248 - (54%)	Gaps:	23/248 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLAGASGEDGKIVNGTTAGPGEFPFVVSLRRAKSGRHSCGATLLNPYWVLTAAHCVRGSSPEQLD 83
            |..|.|.:..::|....|....:|:.||::..|  :|.||.::|:|:||||||||.|    :..|
Human   194 LACGKSLKTPRVVGVEEASVDSWPWQVSIQYDK--QHVCGGSILDPHWVLTAAHCFR----KHTD 252

  Fly    84 -----LQYGSQMLAR-NSSQVARVAAIFVHPGYEPEDKYVNDIALLQLAQSVALSKFVQPVRLP- 141
                 ::.||..|.. .|..||::..|..:|.| |:|   |||||::|...:..|..|:|:.||
Human   253 VFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMY-PKD---NDIALMKLQFPLTFSGTVRPICLPF 313

  Fly   142 EPRQVTPGNASAVLAGWGL-NATGGVVQQHLQKVKLQVFSDTECS--ERHQTYLHDSQICAGLPE 203
            ...::||.....:: |||. ...||.:...|.:..:||...|.|:  :.:|..:.:..:|||:||
Human   314 FDEELTPATPLWII-GWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPE 377

  Fly   204 GGKGQCSGDSGGPLLLIGSDTQ-VGIVSWSIKPCARPPFPGVFTEVSAYVDWI 255
            ||...|.|||||||:....... ||||||.. .|..|..|||:|:||||::||
Human   378 GGVDTCQGDSGGPLMYQSDQWHVVGIVSWGY-GCGGPSTPGVYTKVSAYLNWI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32808	NP_726740.1	Tryp_SPc	29..255	CDD:214473	87/236 (37%)
CG32808	NP_726740.1	Tryp_SPc	30..258	CDD:238113	89/237 (38%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	1/2 (50%)
		Tryp_SPc	204..429	CDD:214473	87/236 (37%)
		Tryp_SPc	205..432	CDD:238113	89/237 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840