DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32808 and PRSS2

DIOPT Version :9

Sequence 1:	NP_726740.1	Gene:	CG32808 / 318221	FlyBaseID:	FBgn0052808	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001290343.1	Gene:	PRSS2 / 5645	HGNCID:	9483	Length:	261	Species:	Homo sapiens

Alignment Length:	270	Identity:	86/270 - (31%)
Similarity:	126/270 - (46%)	Gaps:	29/270 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LFYTATFLLAGASG---EDGKIVNGTTAGPGEFPFVVSLRRAKSGRHSCGATLLNPYWVLTAAHC 73
            |....||:.|..:.   :|.|||.|........|:.|||   .||.|.||.:|::..||::|.||
Human     3 LLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSL---NSGYHFCGGSLISEQWVVSAGHC 64

  Fly    74 V----------RGSSPEQLDLQYGSQML--ARNSSQVARVAAIFVHPGYEPEDKYVNDIALLQLA 126
            .          ||....::.::.|...:  ...:.|....|.|..||.|... ...|||.|::|:
Human    65 YKSAINSKLSGRGCEYHRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSR-TLDNDILLIKLS 128

  Fly   127 QSVALSKFVQPVRLPEPRQVTP--GNASAVLAGWGLNATGGV-VQQHLQKVKLQVFSDTECSERH 188
            ....::..|..:.||    ..|  ....::::|||...:.|. ....||.:...|.|..||...:
Human   129 SPAVINSRVSAISLP----TAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASY 189

  Fly   189 QTYLHDSQICAGLPEGGKGQCSGDSGGPLLLIGSDTQVGIVSWSIKPCARPPFPGVFTEVSAYVD 253
            ...:.::..|.|..||||..|.||||||::..| :.| |||||.. .||:...|||:|:|..|||
Human   190 PGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNG-ELQ-GIVSWGY-GCAQKNRPGVYTKVYNYVD 251

  Fly   254 WIVETVNSYS 263
            ||.:|:.:.|
Human   252 WIKDTIAANS 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32808	NP_726740.1	Tryp_SPc	29..255	CDD:214473	77/240 (32%)
CG32808	NP_726740.1	Tryp_SPc	30..258	CDD:238113	78/242 (32%)
PRSS2	NP_001290343.1	Tryp_SPc	23..253	CDD:214473	77/240 (32%)
PRSS2	NP_001290343.1	Tryp_SPc	24..256	CDD:238113	78/242 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8476
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920