DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32808 and PRSS53

DIOPT Version :9

Sequence 1:	NP_726740.1	Gene:	CG32808 / 318221	FlyBaseID:	FBgn0052808	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	355	Identity:	94/355 - (26%)
Similarity:	145/355 - (40%)	Gaps:	95/355 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MAWL-ARLALFYTATFLLAG------ASGEDG----KIVNGTTAGPGEFPFVVSLRRAKSGRHSC 57
            |.|. ..:.|...||.|:.|      |.|:.|    |...|.|. |||:|:..|:||  .|.|.|
Human     1 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTV-PGEWPWQASVRR--QGAHIC 62

  Fly    58 GATLLNPYWVLTAAHCVRGSSPEQLD---LQYGS---QMLARNSSQVARVAAIFVHPGYEPEDKY 116
            ..:|:...||||||||...::..:|:   :..||   :.|:..:.:|. |||:.:...|....:
Human    63 SGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVG-VAALQLPRAYNHYSQ- 125

  Fly   117 VNDIALLQLAQSVALSKFVQPVRLPEPRQVTPGNASAVLAGWGLNATGGVVQQH----------- 170
            .:|:||||||.....:    |:.||:|....|..||....||..:.:.|.....
Human   126 GSDLALLQLAHPTTHT----PLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGEALCLPS 186

  Fly   171 ----------------------------------LQKVKLQVFSDTEC----SERHQTYLHD--- 194
                                              |:.::|::.|...|    ::.||.:|.:
Human   187 VTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPAR 251

  Fly   195 -SQICAGLPEGGKGQCSGDSGGPLLLIGSD---TQVGIVSWSIKPCARPPFPGVFTEVSAYVDWI 255
             ..:|.|...|.:|.|.||||||:|.:..|   .|.||:|:: ..||:...|.:.|..:|:..|:
Human   252 PGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFA-SSCAQEDAPVLLTNTAAHSSWL 315

  Fly   256 VETVNSYSPPSSLWVGQLIVGRSP--PSLS 283
            ...|.          |...:.:||  |.:|
Human   316 QARVQ----------GAAFLAQSPETPEMS 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32808	NP_726740.1	Tryp_SPc	29..255	CDD:214473	77/287 (27%)
CG32808	NP_726740.1	Tryp_SPc	30..258	CDD:238113	77/289 (27%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	76/283 (27%)
		Tryp_SPc	43..314	CDD:214473	75/280 (27%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010