DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32808 and PRSS54

DIOPT Version :9

Sequence 1:	NP_726740.1	Gene:	CG32808 / 318221	FlyBaseID:	FBgn0052808	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001073961.1	Gene:	PRSS54 / 221191	HGNCID:	26336	Length:	395	Species:	Homo sapiens

Alignment Length:	297	Identity:	74/297 - (24%)
Similarity:	122/297 - (41%)	Gaps:	67/297 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LARLALFYTAT-------FLLAGASGEDGKIVNGTTAGPGEFPFVVSLRRAKSGRHSCGATLLNP 64
            |..|.|.|::|       .:..|...::|.:      ...|||:||||:.::. .|.....:|:.
Human    18 LVLLGLLYSSTSCGVQKASVFYGPDPKEGLV------SSMEFPWVVSLQDSQY-THLAFGCILSE 75

  Fly    65 YWVLTAAHCVRGSSPEQLDLQYGSQMLARNSSQVAR----VAAIFVHPGYEPEDKYVNDIALLQL 125
            :|||:.|..::    .:.|:.....:...:.|::|.    |..|.:|..:: .:...|:||||:.
Human    76 FWVLSIASAIQ----NRKDIVVIVGISNMDPSKIAHTEYPVNTIIIHEDFD-NNSMSNNIALLKT 135

  Fly   126 AQSVALSKFVQPV-RLPEPRQVTPGNASAVLAGWG-LNATGG-VVQQHLQKV-----------KL 176
            ..::.....||.: .|.......|...:..::||. .:|||. :....|:|:           ||
Human   136 DTAMHFGNLVQSICFLGRMLHTPPVLQNCWVSGWNPTSATGNHMTMSVLRKIFVKDLDMCPLYKL 200

  Fly   177 QVFSDTECSERHQTYLHDSQICAGLPEGGKGQCSGDSGGPLL--LIGSDTQV--GIVSWSIKPCA 237
            |   .|||....:             |..|..|.||.|.|::  |...|..|  |::::..:.|
Human   201 Q---KTECGSHTK-------------EETKTACLGDPGSPMMCQLQQFDLWVLRGVLNFGGETC- 248

  Fly   238 RPPFPGVF--TEVSAYVDWIVETVNSYSPP-SSL--W 269
                ||:|  |:|..|..||........|| |||  |
Human   249 ----PGLFLYTKVEDYSKWITSKAERAGPPLSSLHHW 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32808	NP_726740.1	Tryp_SPc	29..255	CDD:214473	59/249 (24%)
CG32808	NP_726740.1	Tryp_SPc	30..258	CDD:238113	61/251 (24%)
PRSS54	NP_001073961.1	Tryp_SPc	52..264	CDD:214473	59/238 (25%)
		Tryp_SPc	52..264	CDD:238113	59/238 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930