Protein Alignment ppk8 and asic1a

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 540
• Identity: 122/540 - (22%)
• Similarity: 203/540 - (37%)
• Gaps: 145/540 - (26%)

  Fly    42 FCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELTSIA 106
            |...:|:||:.:|.:.:..::....:.:..|..|:..:|:..|....:...|.:..:|...|.:.
Zfish    26 FAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVTKLDEITTPVM 90

  Fly   107 NEPFPAVTICNLNQALAERVEHFSND---------------------SVEFAMLQLLCRRKVDVE 150
              .||||||||||.....|:..  ||                     .||.:::::| :.|.|..
Zfish    91 --VFPAVTICNLNSIRFSRITR--NDLYHAGELLALLNSRHEVREAHLVEESVMEVL-KSKTDFR 150

  Fly   151 LVKTNDSRWEEFILNISQPCNSMVIHCRFGA-----DDYECARLFHPIVTDEGLCCVFNMLHPRF 210
            ..|.......||..........|::.|:|..     :|      |..:.|..|.|..||
Zfish   151 SFKPRHFNMWEFYNRTGHDIKDMLLSCQFRGSPCRPED------FSVVFTRYGKCYTFN------ 203

  Fly   211 MYRKRVPYSHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQA 275
                                    ..|.|            |  ||.:...|...||.:.||:|.
Zfish   204 ------------------------SGETG------------P--PRVSVKGGMGNGLEIMLDIQQ 230

  Fly   276 DAYY------CSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDR 334
            |.|.      ..||...|.|:.:||.:|.|.:.:.|..:|||.:|                .|..
Zfish   231 DEYLPVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQT----------------FVSC 279

  Fly   335 RSRRCLFHNELKLRW------------FAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTI 387
            :.:|.::   |...|            |..|:...|..:|.:.:|:.:|.|...:||   .:...
Zfish   280 QEQRLVY---LPAPWGSCKSTPPSSDYFRAYSISACRTDCETRYLVENCNCRMVHMP---GDAPY 338

  Fly   388 C-PLHKRECVE-LIRFRTIIAMESCLDECLPSCFDLSFSAIAYSTRISLDGFRETPSNGG----- 445
            | |:..:||.. .:.|    .:|:..|.|  || :...:...||..:|   |.:.||...
Zfish   339 CTPVLYKECAHPALDF----LVETDSDYC--SC-ETPCNITRYSKELS---FVKIPSKASVKYLA 393

  Fly   446 --WNFTDAYVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAEC--- 505
              ::.::.|:..:|.|::::|:...:...:|.:....:..|..:||.||||:|.|.|:|.|.
Zfish   394 KKYSKSEKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTILELFDY 458

  Fly   506 VYFAL-IRPCRTCSEIRQLN 524
            :|..: .|.|| ||..:..|
Zfish   459 LYEVMKYRLCR-CSNKKHHN 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	115/521 (22%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	117/529 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)