Protein Alignment ppk8 and Asic4

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_071570.2
• Gene: Asic4 / 63882
• RGDID: 621068
• Length: 539
• Species: Rattus norvegicus
• Alignment Length: 569
• Identity: 132/569 - (23%)
• Similarity: 218/569 - (38%)
• Gaps: 149/569 - (26%)

  Fly    37 RNTDEFCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPE 101
            |:...|...:|:|||............|..:.:|||..|:..:|........:.|.|.:|.:||.
  Rat    40 RDLATFASTSTLHGLGRACGPGPHGLRRTLWVLALLTSLAAFLYQAASLARGYLTRPHLVAMDPA 104

  Fly   102 LTS-IANEPFPAVTICNLNQ----ALAER-VEHFSN---------DSVEFAMLQLLCRRKVDVEL 151
            ..: :|.  |||||:||:|:    ||::. :.|.:|         |....|.|:......||: |
  Rat   105 APAPVAG--FPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDI-L 166

  Fly   152 VKTNDSRWEEFILNISQPCNSMVIHCRFGADDYECARLFHPIVTDEGLCCVFNMLHPRFMYRKRV 216
            .:|...     :.::.:.||....||        .|..|..:.|..|.|..||
  Rat   167 NRTGHQ-----LADMLKSCNFSGHHC--------SASNFSVVYTRYGKCYTFN------------ 206

  Fly   217 PYSHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYY-- 279
                                          .|..:.| |.||.|.|.  ||.:.||:|.:.|.
  Rat   207 ------------------------------ADPQSSL-PSRAGGMGS--GLEIMLDIQQEEYLPI 238

  Fly   280 ----CSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCL 340
                ..:|...|.::.:||..|.|.:.:.|..::||.:|.:...      |:.|..:.:....|.
  Rat   239 WRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQ------EQRLTYLPQPWGNCR 297

  Fly   341 FHNELK---LRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHKRECVELIRFR 402
            ..::|:   |:.::.|:...|...|....:::.|.|...:||   .|:||||.:
  Rat   298 AESKLREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP---GNETICPPN----------- 348

  Fly   403 TIIAMESCLDECLPS--------CF-DLSFSAIAYSTRISLDGFRETPSNGG-------WNFTDA 451
              |.:| |.|..|.|        || ....:...|...||:   .:.|:.|.       :|..:.
  Rat   349 --IYIE-CADHTLDSLGGGSEGPCFCPTPCNLTRYGKEISM---VKIPNRGSARYLARKYNRNET 407

  Fly   452 YVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAECVYFALIRPCRT 516
            |:..:..|::::|:..|..|.:|....|.|..|..:||.||||:|.|.|::.|.:.:
  Rat   408 YIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDY-------- 464

  Fly   517 CSEIRQLNQPRVHQMNLKRSPTP-----GNIRYISAADWFQAELAHQQP 560
               |.:::..|:.:: .:|..||     |.|..:..     .||..|.|
  Rat   465 ---IYEVSWDRLKRV-WRRPKTPLRTSTGGISTLGL-----QELKEQSP 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	120/505 (24%)
Asic4	NP_071570.2	ENaC	40..488	CDD:273304	126/546 (23%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	452..454		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..531		2/4 (50%)