DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ppk8 and SCNN1G

DIOPT Version :10

Sequence 1:NP_001036260.3 Gene:ppk8 / 318213 FlyBaseID:FBgn0052792 Length:569 Species:Drosophila melanogaster
Sequence 2:NP_001030.2 Gene:SCNN1G / 6340 HGNCID:10602 Length:649 Species:Homo sapiens


Alignment Length:590 Identity:119/590 - (20%)
Similarity:194/590 - (32%) Gaps:180/590 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 FCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELTSIA 106
            :|.||..||.:.|..|:.|....|:.|..|..|   |:.|.|.|...::...|.|.|......: 
Human    32 YCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAV---ALILWQCALLVFSFYTVSVSIKVHFRKL- 92

  Fly   107 NEPFPAVTICNLNQALAERVEHFSND---SVEFAMLQLL----CRRKVDVE-------------- 150
              .||||||||:|......|.|...|   ....|:..|.    .|::.:.|              
Human    93 --DFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFS 155

  Fly   151 -----LVKTNDSRWE--EFILNISQPCNSMVIHCRFGADDYECARL--FHPIVTDEGLCCVFNM- 205
                 |:...|.:.:  :|.....:.....:||........|..::  |.....|...|..:.. 
Human   156 HRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFS 220

  Fly   206 -----------LH-----PRFMYRKRVPYSH------------------RNISLPEGFHAVNWHA 236
                       ||     .:....|::..|:                  ||.:|   ||    |.
Human   221 SGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTL---FH----HP 278

  Fly   237 ELG----YRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYYCSSSSSIGFKIALHSPNE 297
            ..|    :..|      :|......:.| |...||.:.|.:..:.|.....||.|.|:.:|..:|
Human   279 MHGNCYTFNNR------ENETILSTSMG-GSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDE 336

  Fly   298 SPNVRETGVLLAPGMETKLRI---------DPSKILTEK----HLRNVDRRSRRCLFHNELKLRW 349
            .|.|.:.|..:...|.|.:.:         :|....||.    .:||:                :
Human   337 YPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNI----------------Y 385

  Fly   350 FAHYTQRNCVAECLSGWLIRHCGCVTFYMP----------RLNANDTIC--PLHKRECVELIRFR 402
            .|.|:.:.|:..|....::..|||..:..|          :.:.|...|  .||          |
Human   386 NAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLH----------R 440

  Fly   403 TIIAME-SCLDECLPSCFDLSFSAIAYSTRISLDGFRETPS-------------------NGGWN 447
            ..:..| .|...|..:|   ||.....:|.::     :.||                   |...|
Human   441 AFVQEELGCQSVCKEAC---SFKEWTLTTSLA-----QWPSVVSEKWLLPVLTWDQGRQVNKKLN 497

  Fly   448 FTDAYVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAECV------ 506
            .||      :|.:.:::||...|:..::........||..||.:||::..|.:.:.|.:      
Human   498 KTD------LAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFID 556

  Fly   507 YFALI 511
            :|::|
Human   557 FFSII 561

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk8NP_001036260.3 ASC 42..508 CDD:459966 117/585 (20%)
SCNN1GNP_001030.2 ENaC 24..630 CDD:273304 119/590 (20%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833 135..221 11/85 (13%)
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:17502380 623..627
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.