Protein Alignment ppk8 and SCNN1D

DIOPT Version :9

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 661
• Identity: 131/661 - (19%)
• Similarity: 228/661 - (34%)
• Gaps: 211/661 - (31%)

  Fly    29 STWRRILSRNTDEFCRNTTIHG---LKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWN 90
            :::|.:|:    .||.|.||||   |.....::|:::......:..||.|...:.|:   |::..
Human   218 ASFRELLT----FFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLL---FERHW 275

  Fly    91 TNPVIVGIDPELTSIANEP--FPAVTICNLNQAL-------AERVEHFSNDSVE----------- 135
            ..||::.:     |:.:|.  .|.||:|:.|...       .|.::.|:.::::
Human   276 HRPVLMAV-----SVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGR 335

  Fly   136 FAMLQLLCR--------RKVDVELVKTNDSRWEEFILNIS-QPCNSMVIHCRFGADDYECARLFH 191
            .|:...:.|        |::.::.:..:.||     :.:. :.|||.      |.|   |   |:
Human   336 AALSATVPRHEPPFHLDREIRLQRLSHSGSR-----VRVGFRLCNST------GGD---C---FY 383

  Fly   192 PIVTDEGLCCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVN--------WHAELGYRKRGF--- 245
            ...| .|:..|.:..|                     ||.|:        |....|.:...|
Human   384 RGYT-SGVAAVQDWYH---------------------FHYVDILALLPAAWEDSHGSQDGHFVLS 426

  Fly   246 -QPDG-----------DNPLYPR--------RAQGTGESLGLSLTLDVQADAYYCSSSSSIGFKI 290
             ..||           .:|.|..        .||..|.:.|:.|.|.|:...:....|:..|.::
Human   427 CSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRV 491

  Fly   291 ALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRC----------LFHNEL 345
            .:|..|.:|.:......:.||.|..:.|      .|..:..:......|          |.||
Human   492 MVHGRNHTPFLGHHSFSVRPGTEATISI------REDEVHRLGSPYGHCTAGGEGVEVELLHN-- 548

  Fly   346 KLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHKRECVELIRFRTIIAMES- 409
                 ..||::.|:..|....::..|.| .:|:..|.|....|...:........:|....:|:
Human   549 -----TSYTRQACLVSCFQQLMVETCSC-GYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETH 607

  Fly   410 ---CLDECLPSCFDLSFSAIAYSTRISLDGFRETPS--NGGWNFT---------DAYVER-SVAV 459
               |...|...|.:   ||...||     |....||  :.||...         .::.:| |:|.
Human   608 RLPCTSRCPRPCRE---SAFKLST-----GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAK 664

  Fly   460 VNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAECV------------------ 506
            :|:.:::..:|:.::.........||.:|.|..|:.|.|.||:.|.:
Human   665 INIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRL 729

  Fly   507 ---YFALIR--PCRTCSEIRQLNQPRVHQM----------------NLKRSPTPGNIRYISAAD- 549
               :|:..|  |....|.|:    |...||                :|.|...||.:..:||.:
Human   730 RRAWFSWPRASPASGASSIK----PEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEES 790

  Fly   550 WFQAELAHQQP 560
            |     |..||
Human   791 W-----AGPQP 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	111/575 (19%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211
		ENaC	219..784	CDD:273304	125/641 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777		9/42 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152158
Domainoid	1	1.000	105	1.000	Domainoid score	I6644
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I4949
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800