Protein Alignment ppk8 and SCNN1B

DIOPT Version :9

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 128/650 - (19%)
• Similarity: 216/650 - (33%)
• Gaps: 208/650 - (32%)

  Fly    42 FCRNTTIHGLKYI--NNSKLRSSDRLFFGIALLVVLSLAIYLIQ-----DAFDKWNTNPVIVGID 99
            :|.||..||.|.|  ...|.::   ::|   ||.:|..|:...|     ..:..|.   |.|.:.
Human    48 YCDNTNTHGPKRIICEGPKKKA---MWF---LLTLLFAALVCWQWGIFIRTYLSWE---VSVSLS 103

  Fly   100 PELTSIANEPFPAVTICNLNQALAERVEHFSNDSVEFAMLQLLCRRKVDVELVKTNDSR------ 158
               .......||||||||.:.....:::|...|..|  :::.:..|.:..||...|.:|
Human   104 ---VGFKTMDFPAVTICNASPFKYSKIKHLLKDLDE--LMEAVLERILAPELSHANATRNLNFSI 163

  Fly   159 ----------------------------------------------------------------- 158
                                                                             
Human   164 WNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFT 228

  Fly   159 --------W-------------EEFILNISQPCNSMVIHCRFGAD--DY-ECARLFHPIVTDEGL 199
                    |             ::.::.:|.|...|::.|.|||:  :| ....:|:|   ..|.
Human   229 SATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYP---HYGN 290

  Fly   200 CCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGES 264
            |.:||.    .|..|.:|.:                               ||         |..
Human   291 CYIFNW----GMTEKALPSA-------------------------------NP---------GTE 311

  Fly   265 LGLSLTLDVQADAYYCSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHL 329
            .||.|.||:..:.|....:|:.|.::.||.....|.:|:.|:....|.||.:     .:|.:|..
Human   312 FGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSI-----GVLVDKLQ 371

  Fly   330 RNVDRRSRRCLFHNELKLRWF-----AHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICP 389
            |..:..|...:..:|:.::.|     ..|:.:.|:..|....:||:|.|..:..| |...:..|
Human   372 RMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYP-LPRGEKYC- 434

  Fly   390 LHKRE------CVELIRFRTIIAMESCLDECLPSCFDLSFSAIAYSTRISLDGFRETPSNGG--W 446
             :.|:      |...::. ::...|:|:..|..||.|..     |...||:   .:.||...  |
Human   435 -NNRDFPDWAHCYSDLQM-SVAQRETCIGMCKESCNDTQ-----YKMTISM---ADWPSEASEDW 489

  Fly   447 NFTDAYVER-----------SVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFL 500
            .|.....||           .:..:|:||::..:|..:::........||.:||..|.::|.|.|
Human   490 IFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVL 554

  Fly   501 SIAE----CVYFALIRPCRTCSEIRQLNQPRVHQMNLKRSPTPGNIRYISAADWFQAELAHQQPN 561
            .:.|    .:.|..|...:..:..:.|.|.|.........||...:........||.:.|.:.||
Human   555 CLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	116/595 (19%)
SCNN1B	XP_016879014.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41380
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650