Protein Alignment ppk8 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 125/597 - (20%)
• Similarity: 211/597 - (35%)
• Gaps: 153/597 - (25%)

  Fly    13 ASQQKRSRPQHLQITLSTWRRILSRNTDEFCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSL 77
            |.||..:..:.|.....::|.:.    :.||.||||||...:..|:.......|:.:..|....:
Human    96 APQQPTAEEEALIEFHRSYRELF----EFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGM 156

  Fly    78 AIYLIQDAFDKWNTNPVIVGIDPELTSIANEPFPAVTICNLN----QALAERVEHFSN------- 131
            ..:.....|.::.:.||.:.|:.....:.   |||||||.||    ..:.|.:|....
Human   157 MYWQFGLLFGEYFSYPVSLNINLNSDKLV---FPAVTICTLNPYRYPEIKEELEELDRITEQTLF 218

  Fly   132 DSVEFAMLQLL-----------------------------CRRKVDV-ELVKTNDSR--WEEFIL 164
            |..:::....|                             .||...| ..::.|:.:  |:::.:
Human   219 DLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKI 283

  Fly   165 NISQPCNSMVIHCRF-----GADDYECARLFH------------PIVTDEGL-----CCVFNMLH 207
            .. |.||.....|.:     |.|.......||            |.:.::.|     .|.||.:.
Human   284 GF-QLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVS 347

  Fly   208 PRFMYRKRVPYSHRNISLPEGFHAVNWHAELG--YRKRGFQPDGDNPLYPRRAQGTGESLGLSLT 270
                 ..:..|||        ||    |...|  |.   |....::.|:.....|...  ||||.
Human   348 -----CNQANYSH--------FH----HPMYGNCYT---FNDKNNSNLWMSSMPGINN--GLSLM 390

  Fly   271 LDVQADAYYCSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRI-------------DPSK 322
            |..:.:.:....|:..|.::.:|..:|...:.:.|..|.||:||.:.:             |.:|
Human   391 LRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTK 455

  Fly   323 ILTEKHLRNVDRRSRRCLFHNELKLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTI 387
            ..::..:.|:                :.:.|||:.|:..|....:|:.|||...:.|| ..|...
Human   456 NGSDVPVENL----------------YPSKYTQQVCIHSCFQESMIKECGCAYIFYPR-PQNVEY 503

  Fly   388 CPLHKRECVELIRFRTIIAMES----CLDECLPSCFDLSFSAIAYSTRISLDGFRETPS--NGGW 446
            |...|........::..:...|    |..:|...|...|:...|        |:...||  :..|
Human   504 CDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSA--------GYSRWPSVTSQEW 560

  Fly   447 ---------NFTDAYVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSI 502
                     |:|.......||.||::||:..::.|.::..:.....||.:|....|:.|.|.||:
Human   561 VFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSV 625

  Fly   503 ---AECVYFALI 511
               ||.|:..|:
Human   626 VEMAELVFDLLV 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	119/563 (21%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	121/580 (21%)