DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk8 and asic1b

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	548	Identity:	119/548 - (21%)
Similarity:	204/548 - (37%)	Gaps:	129/548 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FCRNTTIHGLK--YINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELTS 104
            |....::||..  ::.:.|......|:   ||:.:|:::::|:| ..|:     ||..:..:..:
Zfish    69 FFGGCSLHGANHVFVEDKKFSIRQGLW---ALVFLLAISMFLLQ-VVDR-----VIYYLQYDYVT 124

  Fly   105 IANE------PFPAVTICNLNQALAERVEHFSNDSVEFAMLQLL-------CRRKVDVELVKTND 156
            :.:|      .|||:|:||.|.        |....:.::.|..:       ......:.|....|
Zfish   125 LLDERNAKNMTFPAITLCNYNT--------FRRSQLSYSDLLFMGPLLGYEDNMAPGIPLAPEPD 181

  Fly   157 ---SRWE--EFILNISQPCNSMVIHCRFGADDYEC-ARLFHPIVTDEGLCCVFNMLHPRFMYRKR 215
               ||:.  ||........:.|::.|.|...  || |..:..|.|..|.|..||.
Zfish   182 RQGSRFSLAEFFNRTRHRMDDMLLECNFAGK--ECGAEHWREIFTRYGKCYTFNS---------- 234

  Fly   216 VPYSHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYY- 279
                                          ..|| .||......|.|.  ||.:.||:|.|.|.
Zfish   235 ------------------------------GQDG-RPLLITTKGGMGN--GLEIMLDIQQDEYLP 266

  Fly   280 -----CSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRC 339
                 ..::...|.|:.:|:.:|.|.:.:.|..:|||.:|.:...      |:.|..:......|
Zfish   267 VWGETDETTFEAGIKVQIHTQDEPPFIDQLGFGVAPGFQTFVSCQ------EQRLTYLPPPWGDC 325

  Fly   340 LFHNELKLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTIC-PLHKRECVE-LIRFR 402
            . ...:...:|..|:...|..:|.:.:|:.:|.|...:||   .:...| |...:||.: .:.|.
Zfish   326 K-ATPIDSDFFNTYSITACRIDCETRYLVENCNCRMVHMP---GDAPYCTPEQYKECADPALDFL 386

  Fly   403 TIIAMESCLDECLPSCFDLSFSAIAYSTRISLDGFRETPSNGG-------WNFTDAYVERSVAVV 460
            .....:.|:  |...|     :...|...:|   |...||...       :|.|:.|:..::.|:
Zfish   387 VERDNDYCV--CETPC-----NMTRYGKELS---FVRIPSKASAKYLAKKYNKTEQYISDNIMVL 441

  Fly   461 NMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIA-------ECVYFALIRPCRTCS 518
            :::|:...:...:|.:....:..|..:||.||||:|.|.|:|.       |.:.|.|.| |....
Zfish   442 DIFFEALNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILELFDYLYEVIKFKLCR-CAKKK 505

  Fly   519 EIRQLNQPRVHQMNL---KRSPTPGNIR 543
            ..|..|..|...::|   ||.....|:|
Zfish   506 HQRSNNNERGAVLSLDDVKRHAPCDNLR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	107/508 (21%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57
		ASC	66..548	CDD:295594	119/548 (22%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586643
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.900