Protein Alignment ppk8 and asic2

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_005164179.1
• Gene: asic2 / 407669
• ZFINID: ZDB-GENE-040513-4
• Length: 564
• Species: Danio rerio
• Alignment Length: 538
• Identity: 127/538 - (23%)
• Similarity: 209/538 - (38%)
• Gaps: 118/538 - (21%)

  Fly    16 QKRSRPQHLQITLSTWRRILSRNTDEFCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIY 80
            |:|:|.:|.:  ..|.|..|||.|......|.:|||::|.:.....|.|.|:.||....|.|.:
Zfish    43 QRRARRRHTR--PGTPRDDLSRLTVALLSRTRLHGLRHICSPSNSLSRRAFWMIAFCTCLGLLL- 104

  Fly    81 LIQDAFDKWNTNPVIVGID-PELTSIANE-----PFPAVTICNLNQALAERVEHFSNDSVEFA-- 137
                   .|::|.::..:. |..|.:..|     .||.|||||.|..   |:.|.:...:.||
Zfish   105 -------SWSSNRLLHWLAFPTHTRVHTEWAKELAFPTVTICNNNPV---RLYHLTKSDLYFAGH 159

  Fly   138 MLQLLCRRKVDVELV-------------KTND-------SRWE----EFILNISQPCNSMVIHCR 178
            .|.||...:....||             |.:|       .|:|    ||:..:......|::.|:
Zfish   160 WLGLLLANRTARPLVLDLLQDDRRGWFSKLSDFRLFLPPRRFEGTSLEFMDRLGHQLEDMLLACK 224

  Fly   179 FGADDYEC-ARLFHPIVTDEGLCCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVNWHAELGYRK 242
            :..:  .| |..|..:.|..|.|.:||.                              ||.|
Zfish   225 YRGE--PCGAHNFSTVFTRYGKCYMFNA------------------------------AEEG--- 254

  Fly   243 RGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYYC------SSSSSIGFKIALHSPNESPNV 301
                    ..|......|||.  ||.:.||:|.|.|..      .::...|.::.:||..|.|.|
Zfish   255 --------KTLRTTMKGGTGN--GLEIMLDIQQDEYLPVWGETEETAFEAGVRVQIHSQAEPPFV 309

  Fly   302 RETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFHNELKLRWFAHYTQRNCVAECLSGW 366
            .|.|..:|||.:|.:...      |:.|..:......|: ...|....|..|:...|..||.:.:
Zfish   310 HELGFGVAPGFQTFVATQ------EQRLTYLPPPWGECV-SRALDSGLFQVYSVSACRIECETRY 367

  Fly   367 LIRHCGCVTFYMPRLNANDTIC-PLHKRECVELIRFRTIIAMES----CLDECLPSCFDLSFSAI 426
            ::.:|.|...|||   .:...| |...::|.| .....:.|:|.    |...|..:.::...|.:
Zfish   368 IVENCNCRMVYMP---GDSPYCTPEQYKDCAE-PALAALSAVEGTNCICRSPCNMTRYNKELSMV 428

  Fly   427 AYSTRISLDGFRETPSNGGWNFTDAYVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLM 491
            ...::.|.....:.     :|.::.|:..::.|::::|:...:...:|.:....:..|..:||.|
Zfish   429 KIPSKTSARYLEKK-----FNRSEKYITDNILVLDVFFEALNYETIEQKKAYEVAGLLGDIGGQM 488

  Fly   492 GLFLGFSFLSIAECVYFA 509
            |||:|.|.|::.|...:|
Zfish   489 GLFIGASILTLLELFDYA 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	116/509 (23%)
asic2	XP_005164179.1	ENaC	71..538	CDD:273304	117/508 (23%)