Protein Alignment ppk8 and asic4a

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_999952.1
• Gene: asic4a / 407668
• ZFINID: ZDB-GENE-040513-5
• Length: 539
• Species: Danio rerio
• Alignment Length: 573
• Identity: 119/573 - (20%)
• Similarity: 216/573 - (37%)
• Gaps: 139/573 - (24%)

  Fly    42 FCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELTSIA 106
            |...:::||:.:|..|......:..:.:|.||.|:|.:|........:..:|.:..::.|.|  .
Zfish    44 FASASSLHGINHIFVSGRLGVRQTLWALAFLVSLALFLYQAAKCAISYLEHPHVTALNEEAT--P 106

  Fly   107 NEPFPAVTICNLNQ----ALAER-VEHFSNDSVEFAMLQLLCRRK-----VDVE--------LVK 153
            ...||||||||:|:    ||.:. :.|.:|      :..|..:.|     .|:|        :..
Zfish   107 EMVFPAVTICNINRFRFSALTDADIYHLAN------LTGLPPKNKDGHKPTDLEYPAPDMQDIFN 165

  Fly   154 TNDSRWEEFILNISQPCNSMVIHCRFGADDYECARLFHPIVTDEGLCCVFNMLHPRFMYRKRVPY 218
            ....:.||.:    :.||....:|  .|:|      |..:.|..|.|..||
Zfish   166 RTGHQLEEML----KSCNFSGQNC--SAED------FTVVYTRYGKCYTFN-------------- 204

  Fly   219 SHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYY---- 279
                                           .|....|:.:..|...||.:.||:|.|.|.
Zfish   205 -------------------------------GNKTTSRKTKQGGMGNGLEIMLDIQQDDYLPIWK 238

  Fly   280 --CSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFH 342
              ..:|...|.::.:||.:|.|.:.:.|..::||.:|.:...      |:.|..:.:....|...
Zfish   239 ETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQ------EQRLTYLPQPWGNCRST 297

  Fly   343 NELKLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHKRECVELIRFRTIIAM 407
            :|..:..:..|:...|...|.:..::|.|.|...:||. :||  ||.....:||:.   ...:..
Zfish   298 SEQMIPGYDTYSISACRLRCETLEVLRECKCRMVHMPG-DAN--ICTPSDIKCVDK---ALALLQ 356

  Fly   408 ESCLDECLPSCFDLSFSAIAYSTRISLDGFRETPSNGG-------WNFTDAYVERSVAVVNMYFK 465
            :|..|.|.  | :...:...|...:|:   .:.||.|.       ::.::.|:..:..|::::|:
Zfish   357 KSSGDTCF--C-ETPCNLTRYGKELSM---VKIPSKGSARYLSRKYDKSEDYIRDNFLVLDIFFE 415

  Fly   466 DPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAECVYFA----------LIRPCRTCSEI 520
            ...:...:|.:....:..|..:||.||||:|.|.|:|.|.:.:.          |:||.|.
Zfish   416 ALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYVYEVIKHRLERLLRPQRD---- 476

  Fly   521 RQLNQPRVHQMNLKRSPTPGNIRYISAADWFQAELAHQQ--------PNNRQH 565
               ::.:..|.....:....|:..:.|.|..:...:|.:        ||:..|
Zfish   477 ---DKKQTQQQQQASTVATVNLEEMKAKDSSEMSRSHSEGAYANTILPNHHHH 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	107/496 (22%)
asic4a	NP_999952.1	ENaC	44..472	CDD:273304	108/510 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	446..448		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	474..494		2/26 (8%)