DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk8 and asic4a

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	574	Identity:	117/574 - (20%)
Similarity:	218/574 - (37%)	Gaps:	141/574 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELTSIA 106
            |...:::||:.:|..|......:..:.:|.||.|:|.:|........:..:|.:..::.|.|  .
Zfish    44 FASASSLHGINHIFVSGRLGVRQTLWALAFLVSLALFLYQAAKCAISYLEHPHVTALNEEAT--P 106

  Fly   107 NEPFPAVTICNLNQ----ALAER-VEHFSNDSVEFAMLQLLCRRK-----VDVE--------LVK 153
            ...||||||||:|:    ||.:. :.|.:|      :..|..:.|     .|:|        :..
Zfish   107 EMVFPAVTICNINRFRFSALTDADIYHLAN------LTGLPPKNKDGHKPTDLEYPAPDMQDIFN 165

  Fly   154 TNDSRWEEFILNISQPCNSMVIHCRFGADDYECARLFHPIVTDEGLCCVFNMLHPRFMYRKRVPY 218
            ....:.||.:    :.||....:|  .|:|      |..:.|..|.|..||
Zfish   166 RTGHQLEEML----KSCNFSGQNC--SAED------FTVVYTRYGKCYTFN-------------- 204

  Fly   219 SHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYY---- 279
                                           .|....|:.:..|...||.:.||:|.|.|.
Zfish   205 -------------------------------GNKTTSRKTKQGGMGNGLEIMLDIQQDDYLPIWK 238

  Fly   280 --CSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFH 342
              ..:|...|.::.:||.:|.|.:.:.|..::||.:|.:...      |:.|..:.:....|...
Zfish   239 ETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQ------EQRLTYLPQPWGNCRST 297

  Fly   343 NELKLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHKRECVELIRFRTIIAM 407
            :|..:..:..|:...|...|.:..::|.|.|...:||. :||  ||.....:||:    :.:..:
Zfish   298 SEQMIPGYDTYSISACRLRCETLEVLRECKCRMVHMPG-DAN--ICTPSDIKCVD----KALALL 355

  Fly   408 ESCLDECLPSCF-DLSFSAIAYSTRISLDGFRETPSNGG-------WNFTDAYVERSVAVVNMYF 464
            :....:   :|| :...:...|...:|:   .:.||.|.       ::.::.|:..:..|::::|
Zfish   356 QKSSGD---TCFCETPCNLTRYGKELSM---VKIPSKGSARYLSRKYDKSEDYIRDNFLVLDIFF 414

  Fly   465 KDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAECVYFA----------LIRPCRTCSE 519
            :...:...:|.:....:..|..:||.||||:|.|.|:|.|.:.:.          |:||.|.
Zfish   415 EALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYVYEVIKHRLERLLRPQRD--- 476

  Fly   520 IRQLNQPRVHQMNLKRSPTPGNIRYISAADWFQAELAHQQ--------PNNRQH 565
                ::.:..|.....:....|:..:.|.|..:...:|.:        ||:..|
Zfish   477 ----DKKQTQQQQQASTVATVNLEEMKAKDSSEMSRSHSEGAYANTILPNHHHH 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	105/497 (21%)
asic4a	NP_999952.1	ASC	44..472	CDD:295594	106/511 (21%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494		2/26 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586634
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26596
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.800