Protein Alignment ppk8 and asic4b

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_999951.1
• Gene: asic4b / 407667
• ZFINID: ZDB-GENE-040513-6
• Length: 558
• Species: Danio rerio
• Alignment Length: 597
• Identity: 125/597 - (20%)
• Similarity: 224/597 - (37%)
• Gaps: 167/597 - (27%)

  Fly    42 FCRNTTIHGLKYINNSKLRSSDRLFF-----GIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPE 101
            |..::::|||.    ..|.:|:||.|     |:||||  ||.::|.|..   |:....:.  .|.
Zfish    47 FASSSSLHGLA----RALGTSERLGFRQTLWGLALLV--SLGLFLYQAT---WSAATYLE--RPH 100

  Fly   102 LTSIANE-----PFPAVTICNLNQ----ALAER-VEHFSN--------------DSVEFA---ML 139
            |.::..|     .|||:|:||:|:    ||.:. :.|.:|              ..:::.   ||
Zfish   101 LAALREETRRELTFPAITLCNVNRFRFSALTDADIYHLANLTGLPPKSRKGHRPSELQYPPPNML 165

  Fly   140 QLLCRRKVDVELVKTNDSRWEEFILNISQPCNSMVIHCRFGADDYECARLFHPIVTDEGLCCVFN 204
            .:..|....:|              ::.:.||....:|  .::|      |..:.|..|.|..||
Zfish   166 DIFQRTGHQLE--------------DMLKSCNFSGQNC--SSED------FSVVYTRYGKCYTFN 208

  Fly   205 MLHPRFMYRKRVPYSHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSL 269
                                                         .|...|:|.:..|...||.:
Zfish   209 ---------------------------------------------GNKTSPKRVRQGGTGNGLEM 228

  Fly   270 TLDVQADAYY------CSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKH 328
            .||:|.|.|.      ..::...|.::.:||.||.|.:.:.|..::||.:|.:...      |:.
Zfish   229 MLDIQQDEYLPIWRETNETTLEAGIRVQIHSQNEPPYIHQLGFGVSPGFQTFVSCQ------EQR 287

  Fly   329 LRNVDRRSRRCLFHNELKLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHKR 393
            |..:.:....|...:|..:..:..|:...|...|.|..:.|.|.|...:||   .:..||...|.
Zfish   288 LTYLPQPWGNCRASSEPVIPGYDTYSVSACRLHCESTQVQRECNCRMVHMP---GDADICAPSKI 349

  Fly   394 ECVELIRFRTIIAMESCLDECLPSCFDLSFSAIAYSTRISLDGFRETPSNGGWNF-------TDA 451
            :||:    :.:.:::....:..| | :...:...|...:|:   .:.||.|...:       ::.
Zfish   350 KCVD----KALASLQKSTGDSCP-C-ETPCNLTRYGKELSM---VKIPSRGSARYLSRKYQKSEE 405

  Fly   452 YVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAECVYF-------- 508
            |:..:..:::::|:...:...:|.:....:..|..:||.||||:|.|.|:|.|.:.:
Zfish   406 YIRDNFLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAKNK 470

  Fly   509 --ALIRPCRTCSEIRQLN--------QPRVHQMNLKRSPTPGNIRYI--------SAADWFQAEL 555
              .|::|.::..:..|.|        ...:.:.|||...|.|.|..:        :|.|..|...
Zfish   471 IKQLLKPKKSQKQTNQRNLIQEQIQRTKNLREQNLKAQLTAGAIATVRFEEVKVKAANDVAQPHS 535

  Fly   556 AHQQPNNRQHFN 567
            ||.......|.|
Zfish   536 AHPTSVLPNHHN 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	108/510 (21%)
asic4b	NP_999951.1	ENaC	54..497	CDD:273304	111/538 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	450..452		1/1 (100%)