DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk8 and rpk

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	156/541 - (28%)
Similarity:	243/541 - (44%)	Gaps:	90/541 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EFCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIY----LIQDAFDKWNTNPVIVGIDPE 101
            |:||||:|||::|:...:....:|:|:    |.|..::||    |||.|:.||...||||....:
  Fly    38 EYCRNTSIHGVQYLGEQERPFRERIFW----LFVFLISIYGCSTLIQSAYTKWTETPVIVSFAEK 98

  Fly   102 LTSIANEPFPAVTICN-----LNQ-----ALAERVEHFSND----------------SVEFAMLQ 140
            .|.:.|.||||||:|:     |.|     ..|:....||.|                ..||..|.
  Fly    99 STPVWNIPFPAVTVCSETKRVLKQKGKETTYADLYSQFSEDMRASRVFRPENVSALEMEEFRTLL 163

  Fly   141 LLCRRKV---DVELVKTNDSRWEEFILNISQPCNSMVIHCRFGADDYECARLFHPIVTDEGLCCV 202
            .:|..::   |:.|:..:|..:.:.:..:....:....:||:.:...||...|...:|:||:|..
  Fly   164 HVCNTQIIEEDIPLIAGDDLDYFDVLQRMLPQFDRYFFYCRWLSRFGECETFFRKTLTEEGICYT 228

  Fly   203 FNMLHPRFMYR-KRVPYSH-------RNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQ 259
            ||.|....:|| ....|.|       .|||   ..|.. |..|.||..     |.|...:|.|..
  Fly   229 FNGLRATEIYRDDTYQYQHSGEPLEMENIS---SQHTA-WTLETGYAL-----DSDVETFPARVL 284

  Fly   260 GTGESLGLSLTL-DVQADAYYCSSSSSIGFKIA------LHSPNESPNVRETGVLLAPGMETKLR 317
            ..|...|:.|.| ..:.:..|.......|||:.      ||:|::.|.|.:..|.:..|.|..:.
  Fly   285 SAGARSGIFLALQSFKQEVDYACRGPVQGFKVGKFENVLLHAPDDVPQVSKQFVRIPMGKEVLIA 349

  Fly   318 IDPSKILTEKHLRNVDRRSRRCLFHNELKLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLN 382
            :.|:.|.....:.......|:|...:|..||:|..||:.||..|||:.:.:..||||.|.||| |
  Fly   350 VKPNMITMSSGIAEYHPVRRQCFLSHERSLRFFKVYTESNCQLECLANFTLTKCGCVKFSMPR-N 413

  Fly   383 ANDTICPLHKRECVE------LIR-FRTIIAM-----------ESCLDECLPSCFDLSFSAIAYS 429
            .:..:|...|..|.:      |:| |:.:.|:           .:|  .|:|:|     :::.|:
  Fly   414 VDMPVCGEDKIHCYDRAERELLVREFKRVKALNAGRENSRSVESAC--NCMPAC-----TSLVYN 471

  Fly   430 TRISLDGF---RETPSNGGWNFTDAYVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLM 491
            |.||...|   ....:.|...|...|....::.:::|||...|..:|::|..|.::||:..||:.
  Fly   472 TEISQANFDLEEMLVAEGDTEFLKEYPGSQMSRLSIYFKQSQFITSKRSELYGMTEFLANCGGIF 536

  Fly   492 GLFLGFSFLSIAECVYFALIR 512
            |||:|||.||:.|.:|...:|
  Fly   537 GLFMGFSILSLVEMIYHFTLR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	153/534 (29%)
rpk	NP_001246909.1	ASC	39..552	CDD:279230	153/533 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456751
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	11	10.800