DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk8 and ppk28

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	169/541 - (31%)
Similarity:	301/541 - (55%)	Gaps:	47/541 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RRILSRNTDEFCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIV 96
            |..:.|:...:.:|:|:||||||....:...:|:|||:|.::|:.|:::.|.:.:.||:.:|:|:
  Fly    33 RAAIKRSVVYYLKNSTLHGLKYIAEESITIPERIFFGLAFVLVVILSVFFISNVYVKWSASPIII 97

  Fly    97 GIDPELTSIANEPFPAVTICNLNQALAERVEHFSNDSVEFAMLQLLCRRKVD--VELVKTNDSRW 159
            ....:....:|.||||:|||||||||..:|:.....|..|::|..||.:..|  :..:.|    |
  Fly    98 STSAKQKLTSNMPFPAITICNLNQALLSKVDRIGRTSTNFSLLMGLCDQGGDTTISYIGT----W 158

  Fly   160 EEF---ILNISQPCNSMVIHCRFGADDYECARLFHPIVTDEGLCCVFNMLHPRFMYRK-----RV 216
            :.|   :::::|||..|:::|.||:.:.:|:.||..|:||:||||.||.|||.::.|.     |:
  Fly   159 KYFKAILVDVAQPCEKMLLYCSFGSREEDCSWLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRL 223

  Fly   217 PYSHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYYCS 281
            ..:|.|..    :..::|..|.||.:.  .|:.   .:||.:.|||..:||::.|:.....|||:
  Fly   224 ETAHPNTR----YELIDWTPEKGYARN--LPEF---YFPRTSGGTGIRMGLTVVLNASIAEYYCT 279

  Fly   282 SSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFHNELK 346
            .|.|:|||:.:|:|.|.|.|...|.::..|.|.::.|:|........:|::.:..|||||.:|..
  Fly   280 KSMSVGFKVLVHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALPTIRSIKKSVRRCLFSDEND 344

  Fly   347 LRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHKRECVELIR--FRTIIAMES 409
            |.::..|:::||..||.:..|:|.|.||.:|:||::....:|..:..:|.:.::  ..:.:...|
  Fly   345 LAYYRTYSRKNCELECEAKLLLRECSCVLYYLPRIDPLARVCGPNDNQCTDRVQTEIESSLTNLS 409

  Fly   410 CLDECLPSCFDLSFSA-IAYSTRISLDGFRETPSNGGWNFTDAYVERS-VAVVNMYFKDPTFRAN 472
            | :.|.|.||:|::.| ::.::.:|...|:...:...:.|...|...| :::::.|:....||:.
  Fly   410 C-ENCWPGCFELTYRATLSTASIVSDPRFQAGENLPEYIFHGPYSNASEISILHFYYMTNIFRST 473

  Fly   473 KQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAECVYFALIRPCRTCSEIRQLNQPRVHQMN----- 532
            .::|..||::|||..|||:|||:|||..|:.|..::..:||......:||.::.|:.|::
  Fly   474 TKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYITVRPYCASRTLRQRHKRRLEQLSWLTPI 538

  Fly   533 --------------LKRSPTP 539
                          |.|:|.|
  Fly   539 RMPVRRALRRNRGGLLRNPPP 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	157/479 (33%)
ppk28	NP_573169.2	ASC	43..509	CDD:279230	157/479 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469313
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	11	10.800