Protein Alignment ppk8 and Asic2

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_037024.2
• Gene: Asic2 / 25364
• RGDID: 2017
• Length: 563
• Species: Rattus norvegicus
• Alignment Length: 607
• Identity: 125/607 - (20%)
• Similarity: 220/607 - (36%)
• Gaps: 176/607 - (28%)

  Fly    17 KRSRPQHLQITLSTWRRILSRNTDEFCRNTTIHGLKYINNSKLRSSD----RLFFGIALLVVLSL 77
            :|.||.            |||        |.:|||:::...:..:..    |..:.:|....|.|
  Rat    55 RRGRPS------------LSR--------TKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGL 99

  Fly    78 AIYLIQDAFDKWNTNPVIVGID-PELTSIANE-----PFPAVTICNLNQALAERVEHFSNDSVEF 136
            .:        .|::|.::..:. |..|.:..|     ||||||:||.|..   |....|...:.:
  Rat   100 LL--------SWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPL---RFPRLSKGDLYY 153

  Fly   137 A------MLQLLCRRKVDVELVKTNDSR--W--------------------EEFILNISQPCNSM 173
            |      :|.....|.:..||::.::.|  |                    ..|:..:......|
  Rat   154 AGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDM 218

  Fly   174 VIHCRFGADDYECA-RLFHPIVTDEGLCCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVNWHAE 237
            ::.|::..:  .|. ..|..:.|..|.|.:||.
  Rat   219 LLSCKYRGE--LCGPHNFSSVFTKYGKCYMFNS-------------------------------- 249

  Fly   238 LGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYYC------SSSSSIGFKIALHSPN 296
                    ..|| .||......|||.  ||.:.||:|.|.|..      .::...|.|:.:||.:
  Rat   250 --------GEDG-KPLLTTVKGGTGN--GLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQS 303

  Fly   297 ESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFHNELKLRWFAHYTQRNCVAE 361
            |.|.::|.|..:|||.:|.:...      |:.|..:......|. .:|:.|.:|..|:...|..:
  Rat   304 EPPFIQELGFGVAPGFQTFVATQ------EQRLTYLPPPWGECR-SSEMGLDFFPVYSITACRID 361

  Fly   362 CLSGWLIRHCGCVTFYMPRLNANDTIC-PLHKRECVE----LIRFRTIIAMESCLDECLPSCFDL 421
            |.:.:::.:|.|...:||   .:...| |...:||.|    |:..:.   ...||  |...|
  Rat   362 CETRYIVENCNCRMVHMP---GDAPFCTPEQHKECAEPALGLLAEKD---SNYCL--CRTPC--- 415

  Fly   422 SFSAIAYSTRISLDGFRETPSNGG-------WNFTDAYVERSVAVVNMYFKDPTFRANKQTEFIG 479
              :...|:..:|:   .:.||...       :|.::.|:..::.|::::|:...:...:|.:...
  Rat   416 --NLTRYNKELSM---VKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYE 475

  Fly   480 FSDFLSGVGGLMGLFLGFSFLSIAEC--VYFALIRP------------------CRTCSEIRQLN 524
            .:..|..:||.||||:|.|.|:|.|.  ..:.||:.                  ..||..:...:
  Rat   476 VAALLGDIGGQMGLFIGASLLTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHS 540

  Fly   525 QPRVHQMNLKRSPTPGNIRYIS 546
            :...|.:|:......|.:..|:
  Rat   541 ETISHTVNVPLQTALGTLEEIA 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	111/524 (21%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	117/571 (20%)