DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk8 and Scnn1a

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_113736.1	Gene:	Scnn1a / 25122	RGDID:	3639	Length:	699	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	118/559 - (21%)
Similarity:	203/559 - (36%)	Gaps:	129/559 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELTSIA 106
            ||.||||||...:..||.......|:.:..|....:..:.....|:::.:.||.:.|:.....:.
  Rat    88 FCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYLSYPVSLNINLNSDKLV 152

  Fly   107 NEPFPAVTICNLN----QALAERVEHFS--NDSVEFAML--------QLLCRRKVDVEL------ 151
               |||||:|.||    ..:.|.:|...  .:...|.:.        |...||:...:|
  Rat   153 ---FPAVTVCTLNPYRYTEIKEELEELDRITEQTLFDLYKYNSSYTRQAGARRRSSRDLLGAFPH 214

  Fly   152 -----------------------VKTNDSRWEEFILNIS-QPCNSMVIHCRF-----GADDYECA 187
                                   |:.|:.:.:.....|. |.||.....|.:     |.|.....
  Rat   215 PLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREW 279

  Fly   188 RLFH------------PIVTDEGL-----CCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVNWH 235
            ..||            |.:.:|.|     .|.||          :.|.:..|.|   .||    |
  Rat   280 YRFHYINILSRLSDTSPALEEEALGNFIFTCRFN----------QAPCNQANYS---KFH----H 327

  Fly   236 AELG--YRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYYCSSSSSIGFKIALHSPNES 298
            ...|  |.   |....::.|:.....|...  ||||||..:.:.:....|:..|.::.:|..:|.
  Rat   328 PMYGNCYT---FNDKNNSNLWMSSMPGVNN--GLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEP 387

  Fly   299 PNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFHNE---LKLRWFAHYTQRNCVA 360
            ..:.:.|..|.||:||.:.      :.::.|.::......|..:..   :|..:.:.|||:.|:.
  Rat   388 AFMDDGGFNLRPGVETSIS------MRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIH 446

  Fly   361 ECLSGWLIRHCGCVTFYMPRLNANDTICPLHKRE----CVELIRFRTIIAMESCLDECLPSCFDL 421
            .|....:|:.|||...:.|:....: .|...|:.    |...::....:....|..:|...|..:
  Rat   447 SCFQENMIKKCGCAYIFYPKPKGVE-FCDYRKQSSWGYCYYKLQGAFSLDSLGCFSKCRKPCSVI 510

  Fly   422 SFSAIAYSTRISLDGFRETPS--NGGW---------NFTDAYVERSVAVVNMYFKDPTFRANKQT 475
            ::...|        |:...||  :..|         |:|.......||.:|::||:..::.|.::
  Rat   511 NYKLSA--------GYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSES 567

  Fly   476 EFIGFSDFLSGVGGLMGLFLGFSFLSI---AECVYFALI 511
            ..:.....||.:|....|:.|.|.||:   ||.::..|:
  Rat   568 PSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLV 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	117/554 (21%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	118/559 (21%)
Scnn1a	NP_113736.1	deg-1	88..600	CDD:273309	116/551 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345673
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.800