Protein Alignment ppk8 and Scnn1b

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_036780.1
• Gene: Scnn1b / 24767
• RGDID: 3640
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 633
• Identity: 131/633 - (20%)
• Similarity: 224/633 - (35%)
• Gaps: 176/633 - (27%)

  Fly    42 FCRNTTIHGLKYI--NNSKLRSSDRLFFGIAL----LVVLSLAIYLIQDAFDKWNTNPVIVGIDP 100
            :|.||..||.|.|  ...|.::   ::|.:.|    ||.....:::  ..:..|.   |.|.:..
  Rat    29 YCNNTNTHGPKRIICEGPKKKA---MWFLLTLLFACLVCWQWGVFI--QTYLSWE---VSVSLSM 85

  Fly   101 ELTSIANEPFPAVTICNLNQALAERVEHFSND---SVEFAMLQLLCRRKVDVELVKT-NDSRWEE 161
            ...::   .|||||:||.:.....:|:|...|   .:|..:.::|..:........| |.:.|..
  Rat    86 GFKTM---NFPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDKILAPKSSHTNTTSTLNFTIWNH 147

  Fly   162 --------------FILNI-------SQP-----CNSMVIHCRF-----GADDYEC--------- 186
                          .:||:       |.|     ||:.  .|:.     .|:...|
  Rat   148 TPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQ--GCKVAMRLCSANGTVCTFRNFTSAT 210

  Fly   187 -----------ARLFHPIVTDE----G-------LCCVFNMLHPRFMYRKRVPYSHRN---ISLP 226
                       ..:|..::..:    |       |.|:|.          ..|.||||   |..|
  Rat   211 QAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFG----------TEPCSHRNFTPIFYP 265

  Fly   227 E--GFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQADAYYCSSSSSIGFK 289
            :  ..:..||    |..::.. |.. ||         |...||.|.||:..:.|....:|:.|.:
  Rat   266 DYGNCYIFNW----GMTEKAL-PSA-NP---------GTEFGLKLILDIGQEDYVPFLASTAGAR 315

  Fly   290 IALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFH------NELKLR 348
            :.||.....|.:||.|:....|.||.:     .:|.:| |:........|..:      ..|...
  Rat   316 LMLHEQRTYPFIREEGIYAMAGTETSI-----GVLLDK-LQGKGEPYSPCTMNGSDVAIQNLYSD 374

  Fly   349 WFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHKRE------CVELIRFRTIIAM 407
            :...|:.:.|:..|....:|.:|.|..:..| |.|.:..|  :.|:      |...::. :::..
  Rat   375 YNTTYSIQACLHSCFQDHMIHNCSCGHYLYP-LPAGEKYC--NNRDFPDWAYCYLSLQM-SVVQR 435

  Fly   408 ESCLDECLPSCFDLSFSAIAYSTRISLDGFRETPSNGG--W-------------NFTDAYVERSV 457
            |:||..|..||.|..     |...||:   .:.||...  |             |.|  ...:.:
  Rat   436 ETCLSMCKESCNDTQ-----YKMTISM---ADWPSEASEDWILHVLSQERDQSSNIT--LSRKGI 490

  Fly   458 AVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAE-------CVYFALIRPCR 515
            ..:|:||::..:|..:::........||.:||..|.::|.|.|.:.|       .::..:|:...
  Rat   491 VKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVA 555

  Fly   516 TCSEIRQLNQPRVHQMNLKRSPTPGNIRYISAAD--WFQAELAHQQPN 561
            :|..:|:....|.:     ..|.|.....:.|..  .||.:....:||
  Rat   556 SCKGLRRRRPQRPY-----TGPPPTVAELVEAHTNCVFQPDTTSCRPN 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	120/576 (21%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	131/633 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..620		1/1 (100%)
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844	614..618