DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk8 and del-4

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_492230.2	Gene:	del-4 / 189033	WormBaseID:	WBGene00012116	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	594	Identity:	130/594 - (21%)
Similarity:	234/594 - (39%)	Gaps:	145/594 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TDEFCRNTTIHGLKYINNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELT 103
            ||..|..:| ||:.:|..:..|.. |.|:  .|:||:|:|:::.|  |....||.:...::.|.|
Worm    13 TDFSCWTST-HGVPHIGMANARWL-RAFW--ILVVVVSIALFIWQ--FITLLTNYLSFSVNTETT 71

  Fly   104 -SIANEPFPAVTICNLNQ-ALAER----------VEHFSND--SVEFAM-LQLLCRRKVDVE--- 150
             ..|...||.||||:||. .|:|.          ::.:::|  |.:|.: ..|...|:....
Worm    72 LQFAERTFPTVTICHLNPWKLSETKSVDPDMSALIDAYNSDSSSAQFGLPASLTADRQQQASKWT 136

  Fly   151 ---LVKTNDSRWEEFILNISQPCNSMVIHCRFGA--------DDYECARLFHPIVTDEGLCCVFN 204
               ..:.|:.::.: ..:|:...:.||:.|.:.|        :|:     ::|   ..|.|..||
Worm   137 LMYSERLNEKQYND-AADIAYSYDDMVVSCTYNAKTCNITDFNDF-----YNP---SYGNCLQFN 192

  Fly   205 MLHPRFMYRKRVPYSHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSL 269
                                 .:|.::.:        :.|       |||           ||.:
Worm   193 ---------------------TDGMYSSS--------RAG-------PLY-----------GLRM 210

  Fly   270 TLDVQADAYYCSSSSSIGFKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDR 334
            .:....|.|...:.:| |..|.:|..:|.|.....|....||..:.|.:  |.:.|.:    :.:
Worm   211 VMRTDQDTYLPWTEAS-GVIIDIHMQDEIPYPDVFGYFAPPGTASSLGV--SYVQTTR----LSK 268

  Fly   335 RSRRCLFHNELK-LRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDT---------ICP 389
            ....|....:|| ..:...||...|...|:...:|..|||  :|....:|::|         :..
Worm   269 PYGSCTTKTKLKTTHYTGTYTVEACFRSCMQEKIIASCGC--YYPAYSHASNTTQYVSCDNGVQT 331

  Fly   390 LHKRECVELIRFRTIIAMESCLD-ECLPSCFDLSFSAIAYSTRISLDGFRETPSN-----GGWNF 448
            |....||:||........:...| :|...|...|:.....:.:...|.:..|..|     |.|:.
Worm   332 LSNLNCVDLINSADSTEFDVLTDCDCPQPCEIDSYGVTVSTAQWPSDSYVPTECNPGGPSGPWDA 396

  Fly   449 T-----DAYVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAE--CV 506
            :     |.|...:: ::.:|::...|:...::....|.:|:|.|||.:|||||.|.:|..|  .:
Worm   397 SGESCLDWYKANTI-LIEIYYERMNFQVLTESPAYTFVNFISDVGGQVGLFLGMSIISAIEYLVL 460

  Fly   507 YFALIRPCRT----CSEIRQLNQPRVHQMNLKRSPTPGNIRYISA---------ADWFQAELAHQ 558
            .|.:...|.|    .:||.||      :|::|::  ..::..::.         |:.::.:.||.
Worm   461 IFLVFFYCCTHKSRRAEIEQL------EMDIKKA--KDDVDQVAEKRKKHQKANAELYEMDTAHD 517

  Fly   559 QPNNRQHFN 567
            ....:.|.|
Worm   518 IVPPKPHSN 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	114/517 (22%)
del-4	NP_492230.2	ASC	8..466	CDD:295594	117/524 (22%)
del-4	NP_492230.2	deg-1	14..460	CDD:273309	115/517 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4100
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28677
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730