DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk8 and acd-1

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_491295.2	Gene:	acd-1 / 182852	WormBaseID:	WBGene00016064	Length:	635	Species:	Caenorhabditis elegans

Alignment Length:	636	Identity:	124/636 - (19%)
Similarity:	240/636 - (37%)	Gaps:	159/636 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FASQQKRSRPQHLQITLSTWRRI--------LSRNTDEFCRNTTIHGLKYINNSKLRSSDRLFFG 68
            |...|.||: ..:::.::..:::        :.|.|..||..||:||.|.|...|..::  ||:.
Worm    46 FRYNQSRSQ-MIIEVPVAQLKKLRKLEGTVSIKRETQHFCETTTMHGPKRIFQGKRWAT--LFWL 107

  Fly    69 IALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELTSIANE---PFPAVTICNLNQALAERVEHFS 130
            |.:...|.|.|..:.....::.:.|.:    .:::.:.||   .||.:||||||......|...:
Worm   108 IMVSCSLGLLITQVFILASEYLSKPTV----SDVSFLINEDGMDFPLITICNLNPIRKTYVNEIN 168

  Fly   131 -NDSVEFAMLQLLCR-------------------RKVDVELVKTNDSRW--EEFILNISQPCNSM 173
             ...|...|:..:.:                   ...:::|...|...:  :.|.:|....|..:
Worm   169 KTGEVSPPMINYMMKWFTEIPTLIGGADRPTLHEGNEELKLYMKNHLNFTVDSFFMNSGFSCPDI 233

  Fly   174 VIHCRFGADDYECARLFHPIVTDEGLCCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVNWHAEL 238
            ...|.|..:.::|..|...::|..|.|...::                :.|.....|
Worm   234 FKLCSFQGEIFDCCTLSTEVLTPLGKCFTLDL----------------SSSTKASMH-------- 274

  Fly   239 GYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDVQ----------ADAYYCSSSSSIGFKIALH 293
                :..:|              |...||::|||..          .||.:.:|..: ||:..:|
Worm   275 ----KQTEP--------------GIQAGLAITLDAHLEEQFDGSNGMDALFTNSFVN-GFRYFVH 320

  Fly   294 SPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFHNELKLRWFAHYTQRNC 358
            .||..|::......::|.     .:..|.|.:::::.....:...|..:....::....|:..||
Worm   321 PPNTIPHLSSDEFTVSPN-----TVAFSAISSDRYVLLPTHQWGNCTENFPDGIQSNLSYSSGNC 380

  Fly   359 VAECLSGWLIRHCGCVTFYMPRL-NANDTICPLHKRECVELIRFRTIIAMESCLDE--------- 413
            ::.|.:.:.:.:|||.    |.| |..:.:     :||       |.....:|||.
Worm   381 LSLCKAKFYMENCGCT----PALYNIENNL-----KEC-------TPYETTTCLDNILAKPNKET 429

  Fly   414 ------------CLPSCFDLSFSAI-AYSTRISLDGFRETPS-NGGWNFTDAYVERSVAVVNMYF 464
                        |...|..|.:.|. :|.::.|...|....| |..|  ||.::..:..::|:::
Worm   430 GKIEFQTPNCKACAQQCNSLVYRAYNSYGSQFSAGAFHYLKSINPEW--TDGHMRANFQMINIFY 492

  Fly   465 KDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAE-CVYFALI------RPCRTCSEIRQ 522
            :|.::....|.:....:..||.:||.||:|||.|.::|.| |::|:.:      :..|.....::
Worm   493 RDMSYTEYNQVQDASVTQLLSDIGGNMGMFLGMSVITITEICLFFSKMFWLGFSKKRRDYMYSKR 557

  Fly   523 LNQPRVHQM-------NLKRSPTPGNIRYISAADWFQAELAHQQPNNRQHF 566
            :|: :.|:.       .:|...:.||:..|:..    ....:..||:...|
Worm   558 VNE-KTHEREVCETVEKMKAIASQGNLSSIAGT----TSAKNSIPNDNVEF 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	107/525 (20%)
acd-1	NP_491295.2	ASC	83..536	CDD:279230	107/524 (20%)
acd-1	NP_491295.2	deg-1	83..536	CDD:273309	107/524 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28677
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14160
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760