DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk8 and unc-105

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001364812.1	Gene:	unc-105 / 174306	WormBaseID:	WBGene00006832	Length:	974	Species:	Caenorhabditis elegans

Alignment Length:	804	Identity:	140/804 - (17%)
Similarity:	254/804 - (31%)	Gaps:	305/804 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QKRSRPQHLQITLSTWRRILSRNTD-----------------------EFCRNTTIHGLKY--IN 55
            :|||..:.|.    .|||.||.|.:                       .|.:.:|.||:.:  ..
Worm    75 RKRSHNKRLH----DWRRRLSVNPELLRRHGLRNIRMNGHLDWNQLRKSFEKQSTFHGISHAATA 135

  Fly    56 NSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGIDPELTSIANEPFPAVTICNLN- 119
            :.|.|......|.|.||.:|....:||    .|:......|.:|   ....|.|||::||||||
Worm   136 DGKWRWFWYTAFTICLLALLIQIFFLI----SKYRQYGKTVDLD---LKFENAPFPSITICNLNP 193

  Fly   120 ----------------QALAERVEHFSNDSVE--------------------------------- 135
                            :|.:.|:.  |.|..|
Worm   194 YKKSAIQSNPNTKAMMEAYSRRIG--SGDKTEGIAAALSATGGLHAKVRRAKRKAKGKPRLRDRR 256

  Fly   136 --FAMLQLLC-----------------RRKVDVELVKTND------------------------- 156
              .|..|.||                 :.|::::   ||:
Worm   257 YHQAFAQCLCDIEQLTGDRKGSCFAAFKGKIEID---TNNTAGFMNLHTSRCLCQLDTVSKALWP 318

  Fly   157 ----SRWEEFILNISQPCNSMVIHC--RF--GADDYE----------CARLFHPIVT--DEGLCC 201
                |.|:|   .:...|.....||  ||  |.:.||          |.:.::..|:  |:|:..
Worm   319 CFPYSSWKE---KLCSECVDNTGHCPMRFYKGNELYENIKEQVDLCLCHKEYNHCVSTRDDGIIL 380

  Fly   202 ----------------VFNMLHPRFMYRKRVPYSHR-NISLPEGFH------AVNWHAE------ 237
                            :.:.|..:...:..|..:.. .::...||.      |:...|:
Worm   381 EISPNDELNDLDIGKKIASQLSAQQEKQAEVTTTEAPTVTQALGFEELTDDIAITSQAQENLMFA 445

  Fly   238 ----------------------LGYRKRGFQPDGDNPL-------------YPRRAQ----GTGE 263
                                  ..:.::..|.|.|..|             |.|.|:    ..|.
Worm   446 VGEMSEKAKESMSYELDELVLKCSFNQKDCQMDRDFTLHYDNTFGNCYTFNYNRTAEVASHRAGA 510

  Fly   264 SLGLSLTLDVQADAYYCSSSSSIGFKIALHS------PNESPNVRETGVLLAPGMETK--LRIDP 320
            :.||.:.|.... :.|..::.::||:|.:|.      |:.......||.:.:.|:..|  :|::|
Worm   511 NYGLRVLLYANV-SEYLPTTEAVGFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEP 574

  Fly   321 SKILTEKHLRNVDRRSRRCLFHNELKLRWFAH----YTQRNCVAECLSGWLIRHCGCVTFYMP-- 379
                ...|.|           |.......|.:    |:...|...|....::..|||.....|
Worm   575 ----PYGHCR-----------HGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPMYPVA 624

  Fly   380 RLNANDT----ICPLHKRECVELIRF----------RTIIAMESCLDECLPSCFDLSFSAIAYST 430
            .:..|:|    ...:.:|||:.....          ..||....|...|..:.:::::|:..:
Worm   625 EMFGNNTKPCQAVNMDQRECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARW-- 687

  Fly   431 RISLDGFRETPSN---------GGWNFTDAYVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSG 486
                      ||.         |.:...:.| .::.|:|.:::::..:...:::.....:..|:.
Worm   688 ----------PSGSAKVMECLPGDFLCLEKY-RKNAAMVQIFYEELNYETMQESPAYTLTSVLAD 741

  Fly   487 VGGLMGLFLGFSFLSIAECVYF------ALIRPCRTCSEIRQLNQPRVHQMN------LKRSPTP 539
            :|||.||::|.|.:|:.|.|..      |.:|..:.....:..:...||:.:      |.:|.|.
Worm   742 LGGLTGLWIGASVVSLLEIVTLIVFATQAYVRKRKGSISAQSHHSVPVHRASRVSLNTLHKSSTT 806

  Fly   540 GNIRYISAADWFQAELAHQQPNNR 563
            .::: :|..|....:..|...:::
Worm   807 QSVK-LSVMDIRSIKSIHSNHSSK 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	120/686 (17%)
unc-105	NP_001364812.1	deg-1	119..763	CDD:273309	120/687 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4100
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820