Protein Alignment ppk8 and Asic3

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_006535700.1
• Gene: Asic3 / 171209
• MGIID: 2159339
• Length: 563
• Species: Mus musculus
• Alignment Length: 645
• Identity: 131/645 - (20%)
• Similarity: 203/645 - (31%)
• Gaps: 273/645 - (42%)

  Fly    42 FCRNTTIHGLKYI---NNSKLRSSDRLFFGI-ALLVVLSLAIYLIQDA--------------FDK 88
            |..:.|:|||.:|   ....||.      |: |..|:||||.:|.|.|              .|:
Mouse    21 FANSCTMHGLGHIFGPGGLTLRR------GLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDE 79

  Fly    89 WNTNPVIVGIDPELTSIANEPFPAVTICNLNQALAERV------------------EHFS----- 130
            ..::        :||      |||||:||:|.....|:                  ||.:
Mouse    80 RESH--------QLT------FPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRAL 130

  Fly   131 ---------NDSVEFAMLQLLCRRKVDVELVKTNDSRWEEFILNISQPCNSMVIHCRF-----GA 181
                     ..|..|.|.||..|....:|                     .|::.||:     |.
Mouse   131 GQPPAPPGFMPSPTFDMAQLYARAGHSLE---------------------DMLLDCRYRGQPCGP 174

  Fly   182 DDYECARLFHPIVTDEGLCCVFNMLHPRFMYRKRVPYSHRNISLPEGFHAVNWHAELGYRKRGFQ 246
            ::      |..|.|..|.|..||                   |..:|       |||....:|
Mouse   175 EN------FTVIFTRMGQCYTFN-------------------SGAQG-------AELLTTPKG-- 205

  Fly   247 PDGDNPLYPRRAQGTGESLGLSLTLDVQADAYYC------SSSSSIGFKIALHSPNESPNVRETG 305
                         |.|.  ||.:.||||.:.|..      .:...:|.::.:|...|.|.:.:.|
Mouse   206 -------------GAGN--GLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHGQEEPPAIDQLG 255

  Fly   306 VLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFHNELKLRW--------------------- 349
            ...|||.:|.:.....::                   :.|...|
Mouse   256 FGAAPGHQTFVSCQQQQL-------------------SFLPPPWGDCNTASVDPDFDPEPSDPLG 301

  Fly   350 ----FAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTIC-PLHKRECVE------------ 397
                ...|:...|...|.|.::.|.|||...:||   .|..:| |...::|..
Mouse   302 SPSSSPPYSLIGCRLACESRYVARKCGCRMMHMP---GNSPVCSPQQYKDCASPALGKAHLFSLP 363

  Fly   398 -----------------LIRFRTIIAM---ESCLDECLPSCFDLSFSAIAYSTRISLDGFRETPS 442
                             .:..|...||   ::|:  |...|     :...|:..:|:   ...||
Mouse   364 VPIHSDIDHNPLGQVLLFLALRPADAMLRKDTCV--CPNPC-----ATTRYAKELSM---VRIPS 418

  Fly   443 NGG-------WNFTDAYVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFL 500
            ...       :|.::.|:..:|.|::::|:...:.|.:|......|:.|..:||.||||:|.|.|
Mouse   419 RASARYLARKYNRSETYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLL 483

  Fly   501 SIAECVYFALIRPC-------------RTCSEIR--------QLNQPRVHQMNLKRSPTP 539
            :|.|.:.:.    |             |..|:.|        :||..|.|..:|...|.|
Mouse   484 TILEILDYL----CEVFQDRVLGYFWNRRSSQRRSGNTLLQEELNGHRTHVPHLSLGPRP 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	120/591 (20%)
Asic3	XP_006535700.1	ENaC	21..546	CDD:273304	131/645 (20%)