Protein Alignment ppk8 and Asic2

DIOPT Version :10

• Sequence 1: NP_001036260.3
• Gene: ppk8 / 318213
• FlyBaseID: FBgn0052792
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_006532059.1
• Gene: Asic2 / 11418
• MGIID: 1100867
• Length: 596
• Species: Mus musculus
• Alignment Length: 616
• Identity: 135/616 - (21%)
• Similarity: 233/616 - (37%)
• Gaps: 161/616 - (26%)

  Fly    17 KRSRPQHLQITLSTWRRILSRNTDEFCRNTTIHGLKYINNSKLRSSD----RLFFGIALLVVLSL 77
            :|.||.            |||        |.:|||:::...:..:..    |..:.:|....|.|
Mouse    55 RRGRPS------------LSR--------TKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGL 99

  Fly    78 AIYLIQDAFDKWNTNPVIVGID-PELTSIANE-----PFPAVTICNLNQALAERVEHFSNDSVEF 136
            .:        .|::|.::..:. |..|.:..|     ||||||:||.|..   |....|...:.:
Mouse   100 LL--------SWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPL---RFPRLSKGDLYY 153

  Fly   137 A------MLQLLCRRKVDVELVKTNDSRWEEFILNISQPCNSMVIHCRFGADDYECARLFHPIVT 195
            |      :|.....|.:..||::.::.|.:.|               |..||    .|||.|...
Mouse   154 AGHWLGLLLPNRTARPLVSELLRGDEPRRQWF---------------RKLAD----FRLFLPPRH 199

  Fly   196 DEGLCCVF-----NMLHPRFM---YRKRV--PYSHRNIS------------LPEGFHAVNWHAEL 238
            .||:...|     :.|....:   ||..:  |::..::|            ||....|:.|....
Mouse   200 FEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVSCPPREPALSDPALPRSPEALRWAPGT 264

  Fly   239 GYRKRGFQPDG----------DNPLYPRRAQGTGESLGLSLTLDVQADAYYC------SSSSSIG 287
            |::...|...|          ..||......|||.  ||.:.||:|.|.|..      .::...|
Mouse   265 GHQAPVFTKYGKCYMFNSGEDGKPLLTTVKGGTGN--GLEIMLDIQQDEYLPIWGETEETTFEAG 327

  Fly   288 FKIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVDRRSRRCLFHNELKLRWFAH 352
            .|:.:||.:|.|.::|.|..:|||.:|.:...      |:.|..:......|. .:|:.|.:|..
Mouse   328 VKVQIHSQSEPPFIQELGFGVAPGFQTFVATQ------EQRLTYLPPPWGECR-SSEMGLDFFPV 385

  Fly   353 YTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTIC-PLHKRECVE----LIRFRTIIAMESCLD 412
            |:...|..:|.:.:::.:|.|...:||   .:...| |...:||.|    |:..:.   ...||
Mouse   386 YSITACRIDCETRYIVENCNCRMVHMP---GDAPFCTPEQHKECAEPALGLLAEKD---SNYCL- 443

  Fly   413 ECLPSCFDLSFSAIAYSTRISLDGFRETPSNGG-------WNFTDAYVERSVAVVNMYFKDPTFR 470
             |...|     :...|:..:|:   .:.||...       :|.::.|:..::.|::::|:...:.
Mouse   444 -CRTPC-----NLTRYNKELSM---VKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYE 499

  Fly   471 ANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAEC--VYFALIRP------------------CR 515
            ..:|.:....:..|..:||.||||:|.|.|:|.|.  ..:.||:.                  ..
Mouse   500 TIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMS 564

  Fly   516 TCSEIRQLNQPRVHQMNLKRSPTPGNIRYIS 546
            ||..:...::...|.:|:......|.:..|:
Mouse   565 TCDTMPNHSETISHTVNVPLQTALGTLEEIA 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:459966	121/533 (23%)
Asic2	XP_006532059.1	ENaC	64..590	CDD:273304	127/580 (22%)