DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk8 and asic5

DIOPT Version :9

Sequence 1:	NP_001036260.3	Gene:	ppk8 / 318213	FlyBaseID:	FBgn0052792	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_017951381.2	Gene:	asic5 / 100498195	XenbaseID:	XB-GENE-983430	Length:	852	Species:	Xenopus tropicalis

Alignment Length:	548	Identity:	122/548 - (22%)
Similarity:	203/548 - (37%)	Gaps:	146/548 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FCRNTTIHGLKYI-------NNSKLRSSDRLFFGIALLVVLSLAIYLIQDAFDKWNTNPVIVGID 99
            |..:|:.||:..:       .|||.|::   .:...:.|.:.:|.:.:......:.:.|....::
Frog   387 FATSTSFHGVHNLVENGGSGKNSKFRTA---IWTSVVSVFIIMACWQVCTRVINYFSWPTTTSVN 448

  Fly   100 PELTSIANEPFPAVTICNLNQALAERVEHFSNDSVEF-------AMLQLLCRRKVDVELVKTND- 156
            .:.  :.|..|||:|.||||:...:.|   :|.|:.|       |:|..........|:.:..|
Frog   449 VQY--VENIDFPAITFCNLNRFQTKAV---NNLSIAFFLWNIVSAVLHFTSIASDPGEMQEVTDF 508

  Fly   157 ------------SRWEEFILNISQPCNSMVIHCRFGADDYEC-ARLFHPIVTDEGLCCVFNMLHP 208
                        ::...|.||     ||.::.|.|..  |.| ...|..|.|:.|.|..||
Frog   509 LKLNKNFSIKEFTKNYGFYLN-----NSTLLKCSFFG--YPCYPEDFEHIFTEYGNCYTFN---- 562

  Fly   209 RFMYRKRVPYSHRNISLPEGFHAVNWHAELGYRKRGFQPDGDNPLYPRRAQGTGESLGLSLTLDV 273
                                ::.|:.:..:                      |....|||:..|:
Frog   563 --------------------YNTVSMNKRI----------------------TTAGRGLSVLFDI 585

  Fly   274 QADAYYCSSSSSIGF-----KIALHSPNESPNVRETGVLLAPGMETKLRIDPSKILTEKHLRNVD 333
            :...:  :...|:||     ...||||...|.....|:....||...:.:...|.:.::|...
Frog   586 KQTEF--TDEPSLGFVDAGISFVLHSPLVPPRFDGLGLHSPAGMHAHVSMRRFKTVIQEHPWG-- 646

  Fly   334 RRSRRCLFHNELKLRWFAHYTQRNCVAECLSGWLIRHCGCVTFYMPRLNANDTICPLHK-RECVE 397
                .|  :..|||::...|:...|:.||.|.::...|||:.|.:|   .|...|.|.: ..||.
Frog   647 ----EC--NPSLKLKYHEIYSTYGCLQECKSYYIQNECGCIPFLLP---GNGKECDLQQLYNCVS 702

  Fly   398 LIRFRTIIAMESCL-----DECLPSCFDLSFSA-IAYSTRISLDGFRETPSNGGWNFTDA----- 451
            ...: ||...|.|.     ..|...|.:..|.| |:|||         .||:....|..|
Frog   703 RALY-TIEKSELCSMGTYNSTCPVPCEETDFPATISYST---------FPSDKAAQFLSAKLSKS 757

  Fly   452 --YVERSVAVVNMYFKDPTFRANKQTEFIGFSDFLSGVGGLMGLFLGFSFLSIAE---------- 504
              |:..::..:::.:.:..::..||.:.:..|:.||.:||.:|||.|.|.::|.|
Frog   758 ALYMRNNLVYIDIKYHEMNYKIMKQQKALTASELLSNIGGQLGLFCGASMITIIEVLEYLFTNSY 822

  Fly   505 --CVYFALIRPCRTCSEIRQLNQPRVHQ 530
              ||:..|..|  ...|... ||||..:
Frog   823 WMCVFILLKTP--RAPEYTN-NQPRYRE 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk8	NP_001036260.3	ASC	42..508	CDD:279230	115/524 (22%)
asic5	XP_017951381.2	Inhibitor_I29	66..129	CDD:400519
		Peptidase_C1A	158..360	CDD:239068
		ASC	387..816	CDD:395688	113/512 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010