DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tlk and TLK1

DIOPT Version :9

Sequence 1:	NP_001138153.1	Gene:	Tlk / 318206	FlyBaseID:	FBgn0283657	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_036422.3	Gene:	TLK1 / 9874	HGNCID:	11841	Length:	766	Species:	Homo sapiens

Alignment Length:	910	Identity:	374/910 - (41%)
Similarity:	495/910 - (54%)	Gaps:	224/910 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 PGGAGGNTAGLRGSHT--------GGGSKSPSSAQQQQTAAQQQGSGVATGG-------SAGGSA 620
            ||.|....:.|  :||        |...:..|...::|...:.:.:|||:|.       |.|..|
Human    25 PGSAAAARSLL--NHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKA 87

  Fly   621 GNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHV 685
            ....:....|..:|...:..:::|.:::|.:          ||:.::::...|.::|...
Human    88 STNNESSNHSFGSLGSLSDKESETPEKKQSE----------SSRGRKRKAENQNESSQGK----- 137

  Fly   686 VVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVP-------THPHQLGSLG 743
            .:|..||.:|                   ...:.|.|..::....:.|       :|.|...|
Human   138 SIGGRGHKIS-------------------DYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPS-- 181

  Fly   744 VVGMVGVGVGVGVGVNVGVGPPLPPPP-------PMAMPAAIITYSKATQTEVSLHELQEREAEH 801
                            ..|.|..|.|.       |:..|..:  ..|..||::::.:|    |..
Human   182 ----------------SSVRPNSPSPTALAFGDHPIVQPKQL--SFKIIQTDLTMLKL----AAL 224

  Fly   802 ESGKV--------KLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEA 858
            ||.|:        ::|::.|.:.:.:.||...||.::::|..:.|||.:.||||.|||:.||..:
Human   225 ESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 289

  Fly   859 RQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAES 923
            |:|.||:|||||.|.|.|.||:|.|.||||:|||.|.::||.:..:||:|:||:|.|.|::|..:
Human   290 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTA 354

  Fly   924 GRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGA 988
                 |||      |....:.:.:|::|...|
Human   355 -----NNS------QAPSTNSEPKQRKNKAVN--------------------------------- 375

  Fly   989 IGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSD 1053
                                      |.......:.|..|||
Human   376 --------------------------GAENDPFVRPNLPQLL----------------------- 391

  Fly  1054 RGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKL 1118
                                            |..||:|.:||.|||...||||:|::|.|:|:|
Human   392 --------------------------------TLAEYHEQEEIFKLRLGHLKKEEAEIQAELERL 424

  Fly  1119 ERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQL 1183
            ||.|||||||||||.|||.|:|.:||.||:|||||.|||:||||||:|||||.||||.|.|:|||
Human   425 ERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQL 489

  Fly  1184 NKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHK 1248
            ||.|:::||.||.|||.|||.|||.|||||:|||||.|.:|.::||||||||:|:||||||||||
Human   490 NKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHK 554

  Fly  1249 TIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENY 1313
            .:.|:|||||:||:|:||:||||||||:||||||||||||.:|..|||||||||||||:|||::|
Human   555 LMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSY 619

  Fly  1314 NPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATI 1378
            ..| ||||||||||||||||||||||||.|||||:|||||||||||:|||||:|||||||||..|
Human   620 GVD-GMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDI 683

  Fly  1379 LEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPK-HGRGSLN 1442
            |:||||||||||||..||.||:|||:|||.|||||||||.||..||...|:.|.:.: :..|:|:
Human   684 LQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLH 748

Fly 1443 1442
Human 749 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	206/267 (77%)
Tlk	NP_001138153.1	STKc_TLK	1161..1428	CDD:270892	206/266 (77%)
TLK1	NP_036422.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..197		38/225 (17%)
		Smc	209..>454	CDD:224117	113/373 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..383		11/106 (10%)
		STKc_TLK1	449..747	CDD:270942	223/298 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160319
Domainoid	1	1.000	462	1.000	Domainoid score	I481
eggNOG	1	0.900	-	-		E1_KOG1151
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001851
OrthoInspector	1	1.000	-	-		otm40342
orthoMCL	1	0.900	-	-		OOG6_101432
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.700