Protein Alignment Tlk and MPS1

DIOPT Version :9

• Sequence 1: NP_001138153.1
• Gene: Tlk / 318206
• FlyBaseID: FBgn0283657
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_010256.2
• Gene: MPS1 / 851533
• SGDID: S000002186
• Length: 764
• Species: Saccharomyces cerevisiae
• Alignment Length: 587
• Identity: 134/587 - (22%)
• Similarity: 219/587 - (37%)
• Gaps: 179/587 - (30%)

  Fly   904 EREEIDRQ--------KKQLMKKRPAESGRKRNN-NSNQNNQQQQQQQHQQQQQQQNSNSNDSTQ 959
            :||| :||        ::.|.|.|.:.|....|| .:|::|               :..||:.:|
Yeast   252 QREE-NRQAALRKHSSRELLYKSRSSSSSLSSNNLLANKDN---------------SITSNNGSQ 300

  Fly   960 LTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQA 1024
            ....|.||..|.:.|:.:...|..|                               :..||::..
Yeast   301 PRRKVSTGSSSSKSSIEIRRALKEN-------------------------------IDTSNNSNF 334

  Fly  1025 NQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQE 1089
            |..  :|....|...|                       .||.|
Yeast   335 NSP--IHKIYKGISRN-----------------------KDSDS--------------------- 353

  Fly  1090 YYEYDEILKLRQNALKKEDAD--LQLEMEKLER-------ERNLHIRELKRILN----------- 1134
              |..|:  ||..::....||  ||.|.::|:|       ..|::.:.|:...:
Yeast   354 --EKREV--LRNISINANHADNLLQQENKRLKRSLDDAITNENINSKNLEVFYHRPAPKPPVTKK 414

  Fly  1135 -------EDQSRFNNHPVL--ND-RYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKE 1189
                   :..|..||..::  || :|..:.|||:||.|.|:|......:.|.   :.:::.|..:
Yeast   415 VEIVEPAKSASLSNNRNIITVNDSQYEKIELLGRGGSSRVYKVKGSGNRVYA---LKRVSFDAFD 476

  Fly  1190 DKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIP--E 1252
            |...:..|..:.  .:.|..|..||::|.| :|:.......::| |..|||...|.|...:|  .
Yeast   477 DSSIDGFKGEIE--LLEKLKDQKRVIQLLD-YEMGDGLLYLIME-CGDHDLSQILNQRSGMPLDF 537

  Fly  1253 REARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDH 1317
            ...|....:::..:|.:::  ..::|.||||.|.:|    |.|.:||.|||::      |..|:|
Yeast   538 NFVRFYTKEMLLCIKVVHD--AGIVHSDLKPANFVL----VKGILKIIDFGIA------NAVPEH 590

  Fly  1318 GMDLTSQ-GAGTYWYLPPECFVVGK-----------NPPKISSKVDVWSVGVIFYQCLYGKKPFG 1370
            .:::..: ..||..|:.||..|...           |..|:....|:||.|.|.||.:|||.|:|
Yeast   591 TVNIYRETQIGTPNYMAPEALVAMNYTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYG 655

  Fly  1371 HNQSQATILEENTILKA-TEVQF----SNKPTVSNEAKSFIRGCLAYRKED-RMDVFALARHEYI 1429
            ..|.|..:|   .|:.. .::.|    ||...:...|...::.|| ||..| |..|..:....::
Yeast   656 SFQGQNRLL---AIMNPDVKIPFPEHTSNNEKIPKSAIELMKACL-YRNPDKRWTVDKVLSSTFL 716

  Fly  1430 QP 1431
            ||
Yeast   717 QP 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	76/287 (26%)
		STKc_TLK	1161..1428	CDD:270892	76/286 (27%)
MPS1	NP_010256.2	PKc_Mps1	439..716	CDD:271033	82/299 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930