DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tlk and tlk2

DIOPT Version :9

Sequence 1:	NP_001138153.1	Gene:	Tlk / 318206	FlyBaseID:	FBgn0283657	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_001072711.1	Gene:	tlk2 / 780168	XenbaseID:	XB-GENE-5747259	Length:	697	Species:	Xenopus tropicalis

Alignment Length:	792	Identity:	361/792 - (45%)
Similarity:	455/792 - (57%)	Gaps:	185/792 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 VGLGGHPL----------SLASIQ----QQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPH 737
            ||:...||          ||.|:.    :|||   :::|..|:.::::..|..||.....| ..|
Frog    23 VGVAKAPLNSESSNQSLCSLGSLSDKELEQTP---EKKQNDQRNRKRKADPYETSQGKNTP-RGH 83

  Fly   738 QLGSLGVVGMVGVGVGVGVGVNV----------GVGPPLPPP-----PPMAMPA----------A 777
            ::....... .|.|.|...|.:|          .:..|||.|     ||...|.          .
Frog    84 KISDYFEFA-CGSGPGTSPGRSVPPVARSSPQHSLSNPLPLPSQQCSPPSTAPVNPEHSCASFKH 147

  Fly   778 IITYSKATQTEVSLHEL----QEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAK 838
            |....:.||:::::.::    ..:.::.|..:.::|::.|::.:.:.|:...:|.::::|..:.:
Frog   148 ISVQHRCTQSDLTMDKISALENSKSSDLEKKEGRIDDLLRVNCDLRRQMDEQKKMLEKYKERLNR 212

  Fly   839 CIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITA 903
            |:.:.||||.|||..||...|.|.||:|||||.|.|.|.||:|.|.||||||||.|.::||.|..
Frog   213 CVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINT 277

  Fly   904 EREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGP 968
            :||||:||:|.|.|::|...|:    ....||:|:|
Frog   278 QREEIERQRKMLAKRKPPAMGQ----TPPANNEQKQ----------------------------- 309

  Fly   969 GSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNG 1033
                                                             |.|.|         ||
Frog   310 -------------------------------------------------RKNKT---------NG 316

  Fly  1034 GGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILK 1098
            ....                                              |.|..||:|.:||.|
Frog   317 AENE----------------------------------------------ALTLAEYHEQEEIFK 335

  Fly  1099 LRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSE 1163
            ||...||||:|::|.|:|:|||.|||||||||||.|||.|:|.:||.||||||||.|||:|||||
Frog   336 LRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSE 400

  Fly  1164 VHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSF 1228
            |:|||||.||||||.|:|||||:|:::||.||.|||.|||.|||.|||||:|||||.|.:|.:||
Frog   401 VYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF 465

  Fly  1229 CTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNV 1293
            |||||||:|:||||||||||.:.|:||||||||:|:|||||||||||:||||||||||||..|..
Frog   466 CTVLEYCEGNDLDFYLKQHKLMTEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTA 530

  Fly  1294 CGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVI 1358
            |||||||||||||:|||::||...||:|||||||||||||||||||||.|||||:||||||||||
Frog   531 CGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVI 595

  Fly  1359 FYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFAL 1423
            |||||||:|||||||||..||:||||||||||||..||.|:.|||:|||.|||||||||:||..|
Frog   596 FYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQL 660

  Fly  1424 ARHEYIQPPIPK 1435
            |...|:.|.|.|
Frog   661 ACDPYLLPHIRK 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	209/267 (78%)
Tlk	NP_001138153.1	STKc_TLK	1161..1428	CDD:270892	209/266 (79%)
tlk2	NP_001072711.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..136		26/113 (23%)
		Smc	145..>385	CDD:224117	107/376 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..315		11/116 (9%)
		STKc_TLK2	380..688	CDD:270943	228/293 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	462	1.000	Domainoid score	I475
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4993
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001851
OrthoInspector	1	1.000	-	-		otm47518
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3972
SonicParanoid	1	1.000	-	-		X1213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.040