Protein Alignment Tlk and Tlk1

DIOPT Version :10

• Sequence 1: NP_001138153.1
• Gene: Tlk / 318206
• FlyBaseID: FBgn0283657
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_001381947.1
• Gene: Tlk1 / 311118
• RGDID: 1310370
• Length: 766
• Species: Rattus norvegicus
• Alignment Length: 908
• Identity: 374/908 - (41%)
• Similarity: 497/908 - (54%)
• Gaps: 220/908 - (24%)

  Fly   571 PGGAGGNTAGLRGSHT--------GGGSKSPSSAQQQQTAAQQQGSGVATGG-------SAGGSA 620
            ||.|....:.|  :||        |...:..|...::|...:.:.:|||||.       |.|..|
  Rat    25 PGSAAAARSLL--NHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVATGSTGSTGSCSVGAKA 87

  Fly   621 GNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHV 685
            ....:....|..:|...:..:::|.:::|.:          ||:.::::...|.::|...
  Rat    88 STNNESSNHSFGSLGSLSDKESETPEKKQSE----------SSRGRKRKAESQNESSQGK----- 137

  Fly   686 VVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVP-------THPHQLGSLG 743
            .:|..||.:|                   ...:.|.|..::....:.|       :|.|...|
  Rat   138 SIGGRGHKIS-------------------DYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPS-- 181

  Fly   744 VVGMVGVGVGVGVGVNVGVGPPLPPPP-------PMAMPAAIITYSKATQTEVSLHEL------Q 795
                            ..|.|..|.|.       |:..|..:  ..|.|||::::.:|      :
  Rat   182 ----------------SSVRPNSPSPTALAFGDHPVVQPKQL--SFKITQTDLTMLKLAALESTK 228

  Fly   796 EREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQ 860
            .::.|.:.|::  |::.|.:.:.:.||...||.::::|..:.|||.:.||||.|||:.||..:|:
  Rat   229 NQDLEKKEGRI--DDLLRANCDLRRQIDDQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSRE 291

  Fly   861 KCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGR 925
            |.||:|||||.|.|.|.||:|.|.||||:|||.|.::||.:..:||:|:||:|.|.|::|..:
  Rat   292 KSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTA-- 354

  Fly   926 KRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIG 990
               |||      |....:.:.:|::|...|
  Rat   355 ---NNS------QAPATNSEPKQRKNKAVN----------------------------------- 375

  Fly   991 GGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRG 1055
                                    |.......:.|..|||
  Rat   376 ------------------------GAENDPFVRPNLPQLL------------------------- 391

  Fly  1056 GGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLER 1120
                                          |..||:|.:||.|||...||||:|::|.|:|:|||
  Rat   392 ------------------------------TLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLER 426

  Fly  1121 ERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNK 1185
            .|||||||||||.|||.|:|.:||.||:|||||.|||:||||||:|||||.||||.|.|:|||||
  Rat   427 VRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNK 491

  Fly  1186 DWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTI 1250
            .|:::||.||.|||.|||.|||.|||||:|||||.|.:|.::||||||||:|:||||||||||.:
  Rat   492 SWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLM 556

  Fly  1251 PEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNP 1315
            .|:|||||:||:|:||:||||||||:||||||||||||.:|..|||||||||||||:|||::|..
  Rat   557 SEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGV 621

  Fly  1316 DHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILE 1380
            | ||||||||||||||||||||||||.|||||:|||||||||||:|||||:|||||||||..||:
  Rat   622 D-GMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQ 685

  Fly  1381 ENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPK-HGRGSLN 1442
            ||||||||||||..||.||:|||:|||.|||||||||.||..||...|:.|.:.: :..|:|:
  Rat   686 ENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLH 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tlk	NP_001138153.1	STKc_TLK	1161..1428	CDD:270892	206/266 (77%)
Tlk1	NP_001381947.1	EnvC	205..>426	CDD:443969	91/349 (26%)
		STKc_TLK1	449..747	CDD:270942	223/298 (75%)