Protein Alignment Tlk and Tlk2

DIOPT Version :9

• Sequence 1: NP_001138153.1
• Gene: Tlk / 318206
• FlyBaseID: FBgn0283657
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_001178581.1
• Gene: Tlk2 / 303592
• RGDID: 1310907
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 1000
• Identity: 395/1000 - (39%)
• Similarity: 498/1000 - (49%)
• Gaps: 297/1000 - (29%)

  Fly   516 GSGVGAGGAGSGGGGAGSGS-GSGGGKSARLMLPVSDNKKINDYFNKQ------QTGVGVGVPGG 573
            |.||..|...|........| ||...|...     :..||.||..|::      :|..|.|.|.|
  Rat    22 GVGVSKGPLNSESSNQSLCSVGSLSDKEVE-----TPEKKQNDQRNRKRKAEPYETSQGKGTPRG 81

  Fly   574 ---------AGGNTAGLRGSHTGGGSKSP----SSAQQQQT-----AAQQQGSGVATGGSAGGSA 620
                     |||:     |..|..|...|    ||.|...:     ..:|...|: .|.:|..::
  Rat    82 HKISDYFEFAGGS-----GPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL-DGSTAKEAS 140

  Fly   621 GNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHV 685
            ..|..:.|..:..|   |.|:..| :|...:..|..|.:|::           ||.|
  Rat   141 EEQSALPTLMSVML---AKPRLDT-EQLAPRGAGLCFTFVSA-----------QQNS-------- 182

  Fly   686 VVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGV 750
                   |.|..|...:...|.|:|...|.:|.|
  Rat   183 -------PSSTGSGNTEHSCSSQKQISIQHRQTQ------------------------------- 209

  Fly   751 GVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLH-ELQEREAEHESGKVKLDEMTRL 814
                                      :.:|..|.:..|.|.: :|:::|.       ::|::.|.
  Rat   210 --------------------------SDLTIEKISALENSKNSDLEKKEG-------RIDDLLRA 241

  Fly   815 SDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGA 879
            :.:.:.||...||.::::|..:.:|:.:.||||.|||..||...|.|.||:|||||.|.|.|.||
  Rat   242 NCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGA 306

  Fly   880 TFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQ 944
            :|.|.||||||||.|.::||.|.::||||:||:|.|.|::|...|            |.....::
  Rat   307 SFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG------------QAPPATNE 359

  Fly   945 QQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVG 1009
            |:|::..:|..::..|
  Rat   360 QKQRKSKTNGAENETL------------------------------------------------- 375

  Fly  1010 GGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGT 1074
                                                                             
  Rat   376 ----------------------------------------------------------------- 375

  Fly  1075 FLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSR 1139
                       |..||:|.:||.|||...||||:|::|.|:|:|||.|||||||||||.|||.|:
  Rat   376 -----------TLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQ 429

  Fly  1140 FNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYN 1204
            |.:||.||||||||.|||:||||||:|||||.||||||.|:|||||:|:::||.||.|||.|||.
  Rat   430 FKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYR 494

  Fly  1205 IHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYL 1269
            |||.|||||:|||||.|.:|.:|||||||||:|:||||||||||.:.|:||||||||:|:|||||
  Rat   495 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 559

  Fly  1270 NEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPP 1334
            ||||||:||||||||||||..|..|||||||||||||:|||::||...||:||||||||||||||
  Rat   560 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPP 624

  Fly  1335 ECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVS 1399
            |||||||.|||||:|||||||||||||||||:|||||||||..||:||||||||||||..||.|:
  Rat   625 ECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVT 689

  Fly  1400 NEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSST 1464
            .|||:|||.|||||||||:||..||...|:.|.|.|                           |.
  Rat   690 PEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK---------------------------SV 727

  Fly  1465 SQANSTGQTSFSAHMFGNMNQSSSS 1489
            |.::..|....|..  |..|.|||:
  Rat   728 STSSPAGAAIASTS--GASNNSSSN 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	209/267 (78%)
		STKc_TLK	1161..1428	CDD:270892	209/266 (79%)
Tlk2	NP_001178581.1	Smc	206..>503	CDD:224117	158/497 (32%)
		STKc_TLK2	433..741	CDD:270943	232/334 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354373
Domainoid	1	1.000	462	1.000	Domainoid score	I456
eggNOG	1	0.900	-	-		E1_KOG1151
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4993
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001851
OrthoInspector	1	1.000	-	-		otm44472
orthoMCL	1	0.900	-	-		OOG6_101432
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1213
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.700