DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tlk and Tlk2

DIOPT Version :9

Sequence 1:	NP_001138153.1	Gene:	Tlk / 318206	FlyBaseID:	FBgn0283657	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_001106176.1	Gene:	Tlk2 / 24086	MGIID:	1346023	Length:	750	Species:	Mus musculus

Alignment Length:	1000	Identity:	396/1000 - (39%)
Similarity:	499/1000 - (49%)	Gaps:	297/1000 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 GSGVGAGGAGSGGGGAGSGS-GSGGGKSARLMLPVSDNKKINDYFNKQQ------TGVGVGVPGG 573
            |.||..|...|........| ||...|...     :..||.||..|:::      |..|.|.|.|
Mouse    22 GVGVSKGPLNSESSNQSLCSVGSLSDKEVE-----TPEKKQNDQRNRKRKAEPYDTSQGKGTPRG 81

  Fly   574 ---------AGGNTAGLRGSHTGGGSKSP----SSAQQQQT-----AAQQQGSGVATGGSAGGSA 620
                     |||:     |..|..|...|    ||.|...:     .|:|...|: .|.:|..::
Mouse    82 HKISDYFEFAGGS-----GPGTSPGRSVPPVARSSPQHSLSNPLPRRAEQPLYGL-DGSAAKEAS 140

  Fly   621 GNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHV 685
            ..|..:.|..:..|   |.|:..| :|...:..|..|.:|::           ||.|
Mouse   141 EEQSALPTLMSVML---AKPRLDT-EQLAPRGAGLCFTFVSA-----------QQNS-------- 182

  Fly   686 VVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGV 750
                   |.|..|...:...|.|:|...|.:|.|
Mouse   183 -------PSSTGSGNTEHSCSSQKQISIQHRQTQ------------------------------- 209

  Fly   751 GVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLH-ELQEREAEHESGKVKLDEMTRL 814
                                      :.:|..|.:..|.|.: :|:::|.       ::|::.|.
Mouse   210 --------------------------SDLTIEKISALENSKNSDLEKKEG-------RIDDLLRA 241

  Fly   815 SDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGA 879
            :.:.:.||...||.::::|..:.:|:.:.||||.|||..||...|.|.||:|||||.|.|.|.||
Mouse   242 NCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGA 306

  Fly   880 TFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQ 944
            :|.|.||||||||.|.::||.|.::||||:||:|.|.|::|...|            |.....::
Mouse   307 SFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG------------QAPPATNE 359

  Fly   945 QQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVG 1009
            |:|::..:|..::..|
Mouse   360 QKQRKSKTNGAENETL------------------------------------------------- 375

  Fly  1010 GGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGT 1074

Mouse   376 ----------------------------------------------------------------- 375

  Fly  1075 FLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSR 1139
                       |..||:|.:||.|||...||||:|::|.|:|:|||.|||||||||||.|||.|:
Mouse   376 -----------TLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQ 429

  Fly  1140 FNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYN 1204
            |.:||.||||||||.|||:||||||:|||||.||||||.|:|||||:|:::||.||.|||.|||.
Mouse   430 FKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYR 494

  Fly  1205 IHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYL 1269
            |||.|||||:|||||.|.:|.:|||||||||:|:||||||||||.:.|:||||||||:|:|||||
Mouse   495 IHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 559

  Fly  1270 NEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPP 1334
            ||||||:||||||||||||..|..|||||||||||||:|||::||...||:||||||||||||||
Mouse   560 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPP 624

  Fly  1335 ECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVS 1399
            |||||||.|||||:|||||||||||||||||:|||||||||..||:||||||||||||..||.|:
Mouse   625 ECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVT 689

  Fly  1400 NEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSST 1464
            .|||:|||.|||||||||:||..||...|:.|.|.|                           |.
Mouse   690 PEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK---------------------------SV 727

  Fly  1465 SQANSTGQTSFSAHMFGNMNQSSSS 1489
            |.::..|....|..  |..|.|||:
Mouse   728 STSSPAGAAIASTS--GASNNSSSN 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	209/267 (78%)
Tlk	NP_001138153.1	STKc_TLK	1161..1428	CDD:270892	209/266 (79%)
Tlk2	NP_001106176.1	Smc	206..>503	CDD:224117	158/497 (32%)
Tlk2	NP_001106176.1	STKc_TLK2	433..741	CDD:270943	232/334 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850670
Domainoid	1	1.000	462	1.000	Domainoid score	I477
eggNOG	1	0.900	-	-		E1_KOG1151
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4993
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2401
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001851
OrthoInspector	1	1.000	-	-		otm42408
orthoMCL	1	0.900	-	-		OOG6_101432
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3972
SonicParanoid	1	1.000	-	-		X1213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.680