DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tlk and Tlk1

DIOPT Version :9

Sequence 1:	NP_001138153.1	Gene:	Tlk / 318206	FlyBaseID:	FBgn0283657	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_766252.2	Gene:	Tlk1 / 228012	MGIID:	2441683	Length:	766	Species:	Mus musculus

Alignment Length:	908	Identity:	373/908 - (41%)
Similarity:	497/908 - (54%)	Gaps:	220/908 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 PGGAGGNTAGLRGSHT--------GGGSKSPSSAQQQQTAAQQQGSGVATGG-------SAGGSA 620
            ||.|....:.|  :||        |...:..|...::|...:.:.:|||||.       |.|..|
Mouse    25 PGSAAAARSLL--NHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVATGSTGSTGSCSVGAKA 87

  Fly   621 GNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHV 685
            ....:....|..:|...:..:::|.:::|.:          ||:.::::...|.::|...
Mouse    88 STNNESSNHSFGSLGSLSDKESETPEKKQSE----------SSRGRKRKAESQNESSQGK----- 137

  Fly   686 VVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVP-------THPHQLGSLG 743
            .:|..||.:|                   ...:.|.|..::....:.|       :|.|...|
Mouse   138 SIGGRGHKIS-------------------DYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPS-- 181

  Fly   744 VVGMVGVGVGVGVGVNVGVGPPLPPPP-------PMAMPAAIITYSKATQTEVSLHEL------Q 795
                            ..|.|..|.|.       |:..|..:  ..|.|||::::.:|      :
Mouse   182 ----------------SSVRPNSPSPTALAFGDHPVVQPKQL--SFKITQTDLTMLKLAALESTK 228

  Fly   796 EREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQ 860
            .::.|.:.|::  |::.|.:.:.:.||...||.::::|..:.|||.:.||||.|||:.||..:|:
Mouse   229 NQDLEKKEGRI--DDLLRANCDLRRQIDDQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSRE 291

  Fly   861 KCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGR 925
            |.||:|||||.|.|.|.||:|.|.||||:|||.|.::||.:..:||:|:||:|.|.|::|..:
Mouse   292 KSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLGKRKPPTA-- 354

  Fly   926 KRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIG 990
                    ||.|......:.:|::        |:..:|....|
Mouse   355 --------NNSQAPATNSEAKQRK--------TKAVNGAENDP---------------------- 381

  Fly   991 GGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRG 1055
                                          ..:.|..|||
Mouse   382 ------------------------------FVRPNLPQLL------------------------- 391

  Fly  1056 GGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLER 1120
                                          |..||:|.:||.|||...||||:|::|.|:|:|||
Mouse   392 ------------------------------TLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLER 426

  Fly  1121 ERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNK 1185
            .|||||||||||.|||.|:|.:||.||:|||||.|||:||||||:|||||.||||.|.|:|||||
Mouse   427 VRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNK 491

  Fly  1186 DWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTI 1250
            .|:::||.||.|||.|||.|||.|||||:|||||.|.:|.::||||||||:|:||||||||||.:
Mouse   492 SWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLM 556

  Fly  1251 PEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNP 1315
            .|:|||||:||:|:||:||||||||:||||||||||||.:|..|||||||||||||:|||::|..
Mouse   557 SEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGV 621

  Fly  1316 DHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILE 1380
            | ||||||||||||||||||||||||.|||||:|||||||||||:|||||:|||||||||..||:
Mouse   622 D-GMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQ 685

  Fly  1381 ENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPK-HGRGSLN 1442
            ||||||||||||..||.||:|||:|||.|||||||||.||..||...|:.|.:.: :..|:|:
Mouse   686 ENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLH 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	206/267 (77%)
Tlk	NP_001138153.1	STKc_TLK	1161..1428	CDD:270892	206/266 (77%)
Tlk1	NP_766252.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..198		39/226 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..381		10/54 (19%)
		STKc_TLK1	449..747	CDD:270942	223/298 (75%)
		S_TKc	467..734	CDD:214567	206/267 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..766		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850671
Domainoid	1	1.000	462	1.000	Domainoid score	I477
eggNOG	1	0.900	-	-		E1_KOG1151
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001851
OrthoInspector	1	1.000	-	-		otm42408
orthoMCL	1	0.900	-	-		OOG6_101432
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.700