DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tlk and TLK2

DIOPT Version :9

Sequence 1:	NP_001138153.1	Gene:	Tlk / 318206	FlyBaseID:	FBgn0283657	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	XP_024306320.1	Gene:	TLK2 / 11011	HGNCID:	11842	Length:	779	Species:	Homo sapiens

Alignment Length:	1007	Identity:	408/1007 - (40%)
Similarity:	506/1007 - (50%)	Gaps:	289/1007 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 GSGVGAGGAGSGGGGAGSGS-GSGGGKSARLMLPVSDNKKINDYFNKQ------QTGVGVGVPGG 573
            |.||..|...|........| ||...|...     :..||.||..|::      :|..|.|.|.|
Human    29 GVGVSKGPLNSESSNQSLCSVGSLSDKEVE-----TPEKKQNDQRNRKRKAEPYETSQGKGTPRG 88

  Fly   574 ---------AGGNTAGLRGSHTGGGSKSP----SSAQQQQT-----AAQQQGSGVATGGSAGGSA 620
                     |||:..|     |..|...|    ||.|...:     ..:|...|:      .|||
Human    89 HKISDYFEFAGGSAPG-----TSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL------DGSA 142

  Fly   621 GNQVQVQTSSAYALYPP--ASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPP 683
            ..:...:.|:...|...  |.|:..| :|..|:..|..|.:|::           ||.|
Human   143 AKEATEEQSALPTLMSVMLAKPRLDT-EQLAQRGAGLCFTFVSA-----------QQNS------ 189

  Fly   684 HVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMV 748
                     |.|..|...:...|.|:|...|.:|.|
Human   190 ---------PSSTGSGNTEHSCSSQKQISIQHRQTQ----------------------------- 216

  Fly   749 GVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLH-ELQEREAEHESGKVKLDEMT 812
                                        :.:|..|.:..|.|.: :|:::|.       ::|::.
Human   217 ----------------------------SDLTIEKISALENSKNSDLEKKEG-------RIDDLL 246

  Fly   813 RLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRV 877
            |.:.:.:.||...||.::::|..:.:|:.:.||||.|||..||...|.|.||:|||||.|.|.|.
Human   247 RANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRH 311

  Fly   878 GATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQ 942
            ||:|.|.||||||||.|.::||.|.::||||:||:|.|.|::|...|              |...
Human   312 GASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--------------QAPP 362

  Fly   943 HQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGG 1007
            ...:|:|:.|.:|                               ||
Human   363 ATNEQKQRKSKTN-------------------------------GA------------------- 377

  Fly  1008 VGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDS 1072
                       .|.|.             |.||.        .|.|..
Human   378 -----------ENETP-------------SSGNT--------ELKDTA----------------- 393

  Fly  1073 GTFLKPDPVSGAY-----TAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRI 1132
                   |..||:     |..||:|.:||.|||...||||:|::|.|:|:|||.|||||||||||
Human   394 -------PALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRI 451

  Fly  1133 LNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIK 1197
            .|||.|:|.:||.||||||||.|||:||||||:|||||.||||||.|:|||||:|:::||.||.|
Human   452 HNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHK 516

  Fly  1198 HALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQV 1262
            ||.|||.|||.|||||:|||||.|.:|.:|||||||||:|:||||||||||.:.|:||||||||:
Human   517 HACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQI 581

  Fly  1263 VSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAG 1327
            |:|||||||||||:||||||||||||..|..|||||||||||||:|||::||...||:|||||||
Human   582 VNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAG 646

  Fly  1328 TYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQF 1392
            ||||||||||||||.|||||:|||||||||||||||||:|||||||||..||:||||||||||||
Human   647 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQF 711

  Fly  1393 SNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQ 1457
            ..||.|:.|||:|||.|||||||||:||..||...|:.|.|.|
Human   712 PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRK---------------------- 754

  Fly  1458 QQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS 1489
                 |.|.::..|....|..  |..|.|||:
Human   755 -----SVSTSSPAGAAIASTS--GASNNSSSN 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tlk	NP_001138153.1	S_TKc	1161..1429	CDD:214567	209/267 (78%)
Tlk	NP_001138153.1	STKc_TLK	1161..1428	CDD:270892	209/266 (79%)
TLK2	XP_024306320.1	SMC_N	<209..>444	CDD:330553	104/418 (25%)
TLK2	XP_024306320.1	STKc_TLK2	462..770	CDD:270943	232/334 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160318
Domainoid	1	1.000	462	1.000	Domainoid score	I481
eggNOG	1	0.900	-	-		E1_KOG1151
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4993
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2401
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001851
OrthoInspector	1	1.000	-	-		otm40342
orthoMCL	1	0.900	-	-		OOG6_101432
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3972
SonicParanoid	1	1.000	-	-		X1213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.680