DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HNRNPAB and sqd

DIOPT Version :9

Sequence 1:	NP_112556.2	Gene:	HNRNPAB / 3182	HGNCID:	5034	Length:	332	Species:	Homo sapiens
Sequence 2:	NP_731825.1	Gene:	sqd / 41666	FlyBaseID:	FBgn0263396	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	341	Identity:	130/341 - (38%)
Similarity:	179/341 - (52%)	Gaps:	61/341 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    33 GTGAAAGAGGATAAPPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVV 97
            |.|:..|..||     :|:.||:..:|..||...:|..|:|||||||:|::|:|:|:|.|:||:.
  Fly    24 GPGSENGDAGA-----AGSTNGSSDNQSAASGQRDDDRKLFVGGLSWETTEKELRDHFGKYGEIE 83

Human    98 DCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLN 162
            ...:|.||.|||||||.||:|.:..:::||....||.::.:.:|||||.|..    .|||||||.
  Fly    84 SINVKTDPQTGRSRGFAFIVFTNTEAIDKVSAADEHIINSKKVDPKKAKARH----GKIFVGGLT 144

Human   163 PEATEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHTVSGSKCEIK 227
            .|.::|:|:.|||:||.|..:|:|.|.:.::|:||.||||..|:.|..:|:.....::|.:.::|
  Fly   145 TEISDEEIKTYFGQFGNIVEVEMPFDKQKSQRKGFCFITFDSEQVVTDLLKTPKQKIAGKEVDVK 209

Human   228 VAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGGGGQSQSWNQGYGNYWNQGYGYQQGYGPGYGG 292
            .|.||   .:.|...|.||....|.||..||.||.|       ||.|.|: |.|...|||.||||
  Fly   210 RATPK---PENQMMGGMRGGPRGGMRGGRGGYGGRG-------GYNNQWD-GQGSYGGYGGGYGG 263

Human   293 YDYSPYG-YY--GYGPGYDYSQ--------------------------------------GSTNY 316
            |....|| ||  ||..||||..                                      |..|.
  Fly   264 YGAGGYGDYYAGGYYNGYDYGYDGYGYGGGFEGNGYGGGGGGNMGGGRGGPRGGGGPKGGGGFNG 328

Human   317 GKSQRRGGHQNNYKPY 332
            ||.:..||.|..::||
  Fly   329 GKQRGGGGRQQRHQPY 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPAB	NP_112556.2	CBFNT	1..70	CDD:311868	12/36 (33%)
		RRM1_hnRNPAB	66..145	CDD:410151	37/78 (47%)
		RRM2_hnRNPAB	150..229	CDD:409997	31/78 (40%)
sqd	NP_731825.1	RRM_SF	58..129	CDD:302621	33/70 (47%)
sqd	NP_731825.1	RRM2_hnRNPD_like	137..211	CDD:240775	31/73 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8162
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3498
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S1109
OMA	1	1.010	-	-		QHG45859
OrthoDB	1	1.010	-	-		D496221at33208
OrthoFinder	1	1.000	-	-		FOG0001417
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48033
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4769
SonicParanoid	1	1.000	-	-		X985
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	13.020