DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32755 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_727055.1	Gene:	CG32755 / 318192	FlyBaseID:	FBgn0052755	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	247	Identity:	91/247 - (36%)
Similarity:	134/247 - (54%)	Gaps:	27/247 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KIVGGYTVTIDQVPFQVSVRRRSIHERHYGLGHVCGGAVISQRVVCSAAHC-YAINTSVPLVYRD 100
            :||||.:|...:.|:|.||.        .|..|.|||:|::.|.|.:|||| ::...:....:|
Human   217 RIVGGQSVAPGRWPWQASVA--------LGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWR- 272

  Fly   101 PELYVVVAGSSAIDRTDRFTQEYLVQRIVGHKDYNGSTLENDIALLFLNGFIPW-ESPGVRAIPL 164
              ::..:...||:    |..|..||:||:.|..|:....:.|:|||.|...:.: ::.|...:|.
Human   273 --VHAGLVSHSAV----RPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPA 331

  Fly   165 AIKAPEEGTTCLIHGWGKVTMKEKSAS--LQQAPVPILNKELC--QVIYK--LPASQMCAGFLQG 223
            ..:...:|:.|.:.|||........:|  ||...||:.:.:||  ..:|.  |....:|||:|.|
Human   332 KEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDG 396

  Fly   224 GIDACQGDSGGPLIC-DG---RLAGIISWGVGCADPGYPGVYTNVSHFLKWI 271
            ..|||||||||||:| ||   ||.|::|||.|||:|.:||||..|:.||.||
Human   397 RADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32755	NP_727055.1	Tryp_SPc	37..271	CDD:214473	89/245 (36%)
CG32755	NP_727055.1	Tryp_SPc	38..273	CDD:238113	91/246 (37%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133
		Tryp_SPc	217..448	CDD:214473	89/245 (36%)
		Tryp_SPc	218..451	CDD:238113	91/246 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010