DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32755 and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_727055.1	Gene:	CG32755 / 318192	FlyBaseID:	FBgn0052755	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	257	Identity:	87/257 - (33%)
Similarity:	126/257 - (49%)	Gaps:	45/257 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KIVGGYTVTIDQVPFQVSVRRRSIHERHYGLGHVCGGAVISQRVVCSAAHCYAINTSVPLVYRDP 101
            :||||.:......|:|||:..:::        |||||::|:...:.:||||    ...||  .:|
Human   292 RIVGGESALPGAWPWQVSLHVQNV--------HVCGGSIITPEWIVTAAHC----VEKPL--NNP 342

  Fly   102 ELYVVVAGSSAIDRTD--RFTQEYLVQRIVGHKDYNGSTLENDIALLFLNGFIPWE--------- 155
            ..:...||   |.|..  .:...|.|::::.|.:|:..|..|||||:.|...:.:.
Human   343 WHWTAFAG---ILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLP 404

  Fly   156 SPGVRAIPLAIKAPEEGTTCLIHGWGKVTMKEKSAS-LQQAPVPILNKELCQVIY----KLPASQ 215
            :||:      :..||:  .|.|.|||....|.|::. |..|.|.::..:.|...|    .:..:.
Human   405 NPGM------MLQPEQ--LCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAM 461

  Fly   216 MCAGFLQGGIDACQGDSGGPLICDGR----LAGIISWGVGCADPGYPGVYTNVSHFLKWIRR 273
            :|||||||.:|:|||||||||:....    |.|..|||.|||....||||.||..|..||.|
Human   462 ICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32755	NP_727055.1	Tryp_SPc	37..271	CDD:214473	84/253 (33%)
CG32755	NP_727055.1	Tryp_SPc	38..273	CDD:238113	86/254 (34%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133
		Tryp_SPc	292..521	CDD:214473	84/253 (33%)
		Tryp_SPc	293..524	CDD:238113	87/256 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910