DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32755 and PRSS1

DIOPT Version :9

Sequence 1:	NP_727055.1	Gene:	CG32755 / 318192	FlyBaseID:	FBgn0052755	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	290	Identity:	101/290 - (34%)
Similarity:	145/290 - (50%)	Gaps:	40/290 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWMCLLIVATHSGITQSQIGQPT------------ATASPFVILPKIVGGYTVTIDQVPFQVSVR 56
            ||  :|:.......|.||....|            |.|:||....||||||....:.||:|||:.
Human   205 LW--ILVRYKDESSTTSQAHSTTMNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLN 267

  Fly    57 RRSIHERHYGLGHVCGGAVISQRVVCSAAHCYAINTSVPLVYRDPELYVVVAGSSAIDRTDRFTQ 121
            ...         |.|||::|:::.|.||.|||.....|.|...:.|:         ::..::|..
Human   268 SGY---------HFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEV---------LEGNEQFIN 314

  Fly   122 EYLVQRIVGHKDYNGSTLENDIALLFLNGFIPWESPGVRAIPLAIKAPEEGTTCLIHGWGKVTMK 186
               ..:|:.|..|:..||.|||.|:.|:......: .|..|.|....|..||.|||.|||.....
Human   315 ---AAKIIRHPQYDRKTLNNDIMLIKLSSRAVINA-RVSTISLPTAPPATGTKCLISGWGNTASS 375

  Fly   187 --EKSASLQQAPVPILNKELCQVIY--KLPASQMCAGFLQGGIDACQGDSGGPLICDGRLAGIIS 247
              :....||....|:|::..|:..|  |:.::..|.|||:||.|:||||||||::|:|:|.|::|
Human   376 GADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVS 440

  Fly   248 WGVGCADPGYPGVYTNVSHFLKWIRRANAS 277
            ||.|||....|||||.|.:::|||:...|:
Human   441 WGDGCAQKNKPGVYTKVYNYVKWIKNTIAA 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32755	NP_727055.1	Tryp_SPc	37..271	CDD:214473	87/237 (37%)
CG32755	NP_727055.1	Tryp_SPc	38..273	CDD:238113	88/238 (37%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	87/237 (37%)
		Tryp_SPc	249..467	CDD:238113	88/239 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920