DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32755 and KLKB1

DIOPT Version :9

Sequence 1:	NP_727055.1	Gene:	CG32755 / 318192	FlyBaseID:	FBgn0052755	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	272	Identity:	96/272 - (35%)
Similarity:	142/272 - (52%)	Gaps:	45/272 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KIVGGYTVTIDQVPFQVSVRRRSIHERHYGLGHVCGGAVISQRVVCSAAHCYAINTSVPL--VYR 99
            :||||...:..:.|:|||::.:...:|     |:|||::|..:.|.:||||:   ..:||  |:|
Human   401 RIVGGTNSSWGEWPWQVSLQVKLTAQR-----HLCGGSLIGHQWVLTAAHCF---DGLPLQDVWR 457

  Fly   100 DPELYVVVAGSSAIDRTDRFTQEYLVQRIVGHKDYNGSTLENDIALLFLN---GFIPWESPGVRA 161
               :|..:...|.|.:...|:|   ::.|:.|::|..|...:||||:.|.   .:..::.|
Human   458 ---IYSGILNLSDITKDTPFSQ---IKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKP---- 512

  Fly   162 IPLAIKAPEEG------TTCLIHGWGKVTMKEKSA---SLQQAPVPILNKELCQ---VIYKLPAS 214
                |..|.:|      |.|.:.|||  ..|||..   .||:..:|::..|.||   ..||:...
Human   513 ----ICLPSKGDTSTIYTNCWVTGWG--FSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQR 571

  Fly   215 QMCAGFLQGGIDACQGDSGGPLIC--DG--RLAGIISWGVGCADPGYPGVYTNVSHFLKWIRRAN 275
            .:|||:.:||.|||:|||||||:|  :|  ||.||.|||.|||....|||||.|:.::.||....
Human   572 MVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKT 636

  Fly   276 ASLDYSEYRQIP 287
            .|.|.....|.|
Human   637 QSSDGKAQMQSP 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32755	NP_727055.1	Tryp_SPc	37..271	CDD:214473	90/254 (35%)
CG32755	NP_727055.1	Tryp_SPc	38..273	CDD:238113	92/255 (36%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	90/254 (35%)
		Tryp_SPc	402..632	CDD:238113	90/253 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910