DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32755 and TMPRSS12

DIOPT Version :9

Sequence 1:	NP_727055.1	Gene:	CG32755 / 318192	FlyBaseID:	FBgn0052755	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_872365.2	Gene:	TMPRSS12 / 283471	HGNCID:	28779	Length:	348	Species:	Homo sapiens

Alignment Length:	256	Identity:	83/256 - (32%)
Similarity:	127/256 - (49%)	Gaps:	40/256 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KIVGGYTVTIDQVPFQVSVRRRSIHERHYG--LGHVCGGAVISQRVVCSAAHCYAINTSVPLVYR 99
            :|:||........|:.||::.:      ||  |.|||||.::.:|.|.:||||....:
Human    77 RIIGGTEAQAGAWPWVVSLQIK------YGRVLVHVCGGTLVRERWVLTAAHCTKDAS------- 128

  Fly   100 DPELYVVVAGSSAIDRTDRFTQEYLVQRIVGHKDYNGSTLENDIALLFL------NGFIPWESPG 158
            ||.::..|.|::.|......|::..::.|:.|.::...:..|||||..|      |.:|   .|
Human   129 DPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYI---QP- 189

  Fly   159 VRAIPLAIKAPEEGTT-CLIHGWGKVTMKEKSAS--LQQAPVPILNKELCQVIYK----LPASQM 216
             ..:|..:....:|.| |.|.|||: |.:|.:|:  ||.|.|..:::|:|.....    :|.:..
Human   190 -ICLPFDVFQILDGNTKCFISGWGR-TKEEGNATNILQDAEVHYISREMCNSERSYGGIIPNTSF 252

  Fly   217 CAGFLQGGIDACQGDSGGPLIC------DGRLAGIISWGVGCADPGYPGVYTNVSHFLKWI 271
            |||...|..|.|:|||||||:|      ...:.||.|:|.||...|:||||...|.:.||:
Human   253 CAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWL 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32755	NP_727055.1	Tryp_SPc	37..271	CDD:214473	82/254 (32%)
CG32755	NP_727055.1	Tryp_SPc	38..273	CDD:238113	83/255 (33%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..63
TMPRSS12	NP_872365.2	Tryp_SPc	78..316	CDD:238113	83/255 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910