DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32755 and F12

DIOPT Version :9

Sequence 1:	NP_727055.1	Gene:	CG32755 / 318192	FlyBaseID:	FBgn0052755	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	266	Identity:	93/266 - (34%)
Similarity:	131/266 - (49%)	Gaps:	43/266 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LPKIVGGYTVTIDQVPFQVSVRRRSIHERHYGL--GH-VCGGAVISQRVVCSAAHCYAINTSVPL 96
            :.::|||.            |..|..|.....|  || .|.|::|:...|.:||||.....:
Human   370 MTRVVGGL------------VALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPA--- 419

  Fly    97 VYRDPELYVVVAGSSAIDRTDRFTQEYLVQRIVGHKDYNGSTLENDIALLFL----NGFIPWESP 157
                ||...||.|....:.:....|...|:....|:.::..:.::|:|||.|    :|.....||
Human   420 ----PEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP 480

  Fly   158 GVR--AIPLAIKAPEEGTTCLIHGWGK--VTMKEKSASLQQAPVPILNKELCQV--IYK---LPA 213
            .|:  .:|.....|.|.|.|.:.|||.  ...:|.::.||:|.||.|:.|.|..  ::.   ||
Human   481 YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILP- 544

  Fly   214 SQMCAGFLQGGIDACQGDSGGPLICDGR-------LAGIISWGVGCADPGYPGVYTNVSHFLKWI 271
            ..:|||||:||.|||||||||||:|:.:       |.||||||.||.|...|||||:|:::|.||
Human   545 GMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWI 609

  Fly   272 RRANAS 277
            |....|
Human   610 REHTVS 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32755	NP_727055.1	Tryp_SPc	37..271	CDD:214473	89/256 (35%)
CG32755	NP_727055.1	Tryp_SPc	38..273	CDD:238113	91/257 (35%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359
		Tryp_SPc	372..609	CDD:214473	89/256 (35%)
		Tryp_SPc	373..612	CDD:238113	92/258 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910