DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32755 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_727055.1	Gene:	CG32755 / 318192	FlyBaseID:	FBgn0052755	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	278	Identity:	88/278 - (31%)
Similarity:	139/278 - (50%)	Gaps:	64/278 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KIVGGYTVTIDQVPFQVSVRRRSIHERHYGLGHVCGGAVISQRVVCSAAHCYAINTSVPLVYRDP 101
            :||||...:..:.|:|.|::.|.        .|:||||:|:.|.|.:||||:..::....|
Human   567 RIVGGAVSSEGEWPWQASLQVRG--------RHICGGALIADRWVITAAHCFQEDSMASTV---- 619

  Fly   102 ELYVVVAGSSAIDRTDRFTQE--YLVQRIVGHKDYNGSTLENDIALLFLNGFIPWESPGVRAI-- 162
             |:.|..|.  :.:..|:..|  :.|.|::.|..:...:.:.|:|||.|      :.|.||:.
Human   620 -LWTVFLGK--VWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQL------DHPVVRSAAV 675

  Fly   163 -PLAIKAP----EEGTTCLIHGWGKVTMKEK-------------------------SASLQQAPV 197
             |:.:.|.    |.|..|.|.|||  .::|.                         |.:||:..|
Human   676 RPVCLPARSHFFEPGLHCWITGWG--ALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDV 738

  Fly   198 PILNKELCQVIYKLPAS--QMCAGFLQGGIDACQGDSGGPLIC---DGR--LAGIISWGVGCADP 255
            .::.::||..:|:...:  .:|||:.:|..|||||||||||:|   .||  |||::|||:||..|
Human   739 QLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRP 803

  Fly   256 GYPGVYTNVSHFLKWIRR 273
            .|.||||.::..:.||::
Human   804 NYFGVYTRITGVISWIQQ 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32755	NP_727055.1	Tryp_SPc	37..271	CDD:214473	86/274 (31%)
CG32755	NP_727055.1	Tryp_SPc	38..273	CDD:238113	88/275 (32%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	88/277 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910