DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32751 and VNN1

DIOPT Version :9

Sequence 1:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_004657.2	Gene:	VNN1 / 8876	HGNCID:	12705	Length:	513	Species:	Homo sapiens

Alignment Length:	538	Identity:	144/538 - (26%)
Similarity:	230/538 - (42%)	Gaps:	111/538 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGLMLNLSQQASLFKRDFYTAGVVEFE---PSNELS-----DNLA---GYLEIIQSQNATSTD-- 66
            :.::|....:||.  :|.:||.|.|..   |:..|:     :.||   ..|:|::....::.|
Human     9 VAILLFYVSRASC--QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQG 71

  Fly    67 --IIVFPESTL---NSAGSTTF-----VPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYI 121
              |||.||..:   |....:.:     :|:||....|| ::.|..........|||.|:|.|.|:
Human    72 AHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPC-NNRNRFGQTPVQERLSCLAKNNSIYV 135

  Fly   122 VINLTEKQKCEDIPEDTR--PCASNGLNVFNTNVVFDRQGVVVSRYRKVHLY-GE-----PKNST 178
            |.|:.:|:.|     ||.  .|..:|...:||:||||.||.:|:||.|.:|: ||     ||.
Human   136 VANIGDKKPC-----DTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKE-- 193

  Fly   179 FLPELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTVNGIFSSKA 243
              ||:.||.|.|| :||.|.||||||:.||..|:.:..:...|:|..|.:.||.|:        |
Human   194 --PEIVTFNTTFG-SFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLS--------A 247

  Fly   244 VQIQLGWSYANNVNLLAAGASDPIVGNSGSGIYHGRSG-SLRSVMRQESGERSI----------- 296
            |:....|:....||.||:....|....:|||||...|. :....|:.|.|:..:
Human   248 VEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSA 312

  Fly   297 ---YVARVPKYRAKRRMKRDLKRQVATSSSFNIKRDYLENFTSEELKIDAGKIGNLSQNLCHGGF 358
               :.:......|.....::.|..|           :.:.||..:|   .|..||.:  :|....
Human   313 VVNWTSYASSIEALSSGNKEFKGTV-----------FFDEFTFVKL---TGVAGNYT--VCQKDL 361

  Fly   359 CCHFDLAWRSLGKPSRNTSHYSYRVGIYEGWRN-EKRLDVNYIRNCGVFTCSGNSIDDCGQLLPD 422
            |||...      |.|.|..:..|.:|.::|... |.|.   |::.|.:..|...:::.||.   .
Human   362 CCHLSY------KMSENIPNEVYALGAFDGLHTVEGRY---YLQICTLLKCKTTNLNTCGD---S 414

  Fly   423 IQRPLVTFTHVEIRVTYPQSREFLLFPDTLL-DNLLPLEPKQFEWSQKRISEESHQVRFALRKSL 486
            .:.....|....:..|:...   .:||:.|| :|  .|.|.:|:     :|.:..  .|:|:.:
Human   415 AETASTRFEMFSLSGTFGTQ---YVFPEVLLSEN--QLAPGEFQ-----VSTDGR--LFSLKPT- 466

  Fly   487 EVKHLLTFGIYGNYYNNE 504
             ...:||..::|..|..:
Human   467 -SGPVLTVTLFGRLYEKD 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	100/341 (29%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	40/180 (22%)
VNN1	NP_004657.2	biotinidase_like	25..330	CDD:143591	98/323 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157428
Domainoid	1	1.000	106	1.000	Domainoid score	I6567
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8613
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.660