Protein Alignment CG32751 and VNN1

DIOPT Version :10

• Sequence 1: NP_001284927.1
• Gene: CG32751 / 318189
• FlyBaseID: FBgn0052751
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_004657.2
• Gene: VNN1 / 8876
• HGNCID: 12705
• Length: 513
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 144/538 - (26%)
• Similarity: 230/538 - (42%)
• Gaps: 111/538 - (20%)

  Fly    15 LGLMLNLSQQASLFKRDFYTAGVVEFE---PSNELS-----DNLA---GYLEIIQSQNATSTD-- 66
            :.::|....:||.  :|.:||.|.|..   |:..|:     :.||   ..|:|::....::.|
Human     9 VAILLFYVSRASC--QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQG 71

  Fly    67 --IIVFPESTL---NSAGSTTF-----VPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYI 121
              |||.||..:   |....:.:     :|:||....|| ::.|..........|||.|:|.|.|:
Human    72 AHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPC-NNRNRFGQTPVQERLSCLAKNNSIYV 135

  Fly   122 VINLTEKQKCEDIPEDTR--PCASNGLNVFNTNVVFDRQGVVVSRYRKVHLY-GE-----PKNST 178
            |.|:.:|:.|     ||.  .|..:|...:||:||||.||.:|:||.|.:|: ||     ||.
Human   136 VANIGDKKPC-----DTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKE-- 193

  Fly   179 FLPELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTVNGIFSSKA 243
              ||:.||.|.|| :||.|.||||||:.||..|:.:..:...|:|..|.:.||.|:        |
Human   194 --PEIVTFNTTFG-SFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLS--------A 247

  Fly   244 VQIQLGWSYANNVNLLAAGASDPIVGNSGSGIYHGRSG-SLRSVMRQESGERSI----------- 296
            |:....|:....||.||:....|....:|||||...|. :....|:.|.|:..:
Human   248 VEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSA 312

  Fly   297 ---YVARVPKYRAKRRMKRDLKRQVATSSSFNIKRDYLENFTSEELKIDAGKIGNLSQNLCHGGF 358
               :.:......|.....::.|..|           :.:.||..:|   .|..||.:  :|....
Human   313 VVNWTSYASSIEALSSGNKEFKGTV-----------FFDEFTFVKL---TGVAGNYT--VCQKDL 361

  Fly   359 CCHFDLAWRSLGKPSRNTSHYSYRVGIYEGWRN-EKRLDVNYIRNCGVFTCSGNSIDDCGQLLPD 422
            |||...      |.|.|..:..|.:|.::|... |.|.   |::.|.:..|...:::.||.   .
Human   362 CCHLSY------KMSENIPNEVYALGAFDGLHTVEGRY---YLQICTLLKCKTTNLNTCGD---S 414

  Fly   423 IQRPLVTFTHVEIRVTYPQSREFLLFPDTLL-DNLLPLEPKQFEWSQKRISEESHQVRFALRKSL 486
            .:.....|....:..|:...   .:||:.|| :|  .|.|.:|:     :|.:..  .|:|:.:
Human   415 AETASTRFEMFSLSGTFGTQ---YVFPEVLLSEN--QLAPGEFQ-----VSTDGR--LFSLKPT- 466

  Fly   487 EVKHLLTFGIYGNYYNNE 504
             ...:||..::|..|..:
Human   467 -SGPVLTVTLFGRLYEKD 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	100/341 (29%)
		Vanin_C	324..503	CDD:465946	40/180 (22%)
VNN1	NP_004657.2	biotinidase_like	25..330	CDD:143591	98/323 (30%)
		Vanin_C	333..483	CDD:465946	42/191 (22%)