DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32751 and BTD

DIOPT Version :9

Sequence 1:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001268652.2	Gene:	BTD / 686	HGNCID:	1122	Length:	523	Species:	Homo sapiens

Alignment Length:	573	Identity:	156/573 - (27%)
Similarity:	229/573 - (39%)	Gaps:	123/573 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AKNYWGFFL---FCLALGLMLNLSQQASLFKRDFYTAGVVEF---------------EPSNELSD 48
            |::....||   :.:|||........|...:.::|.|.|.|.               |....::.
Human     4 ARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQEALELMNQ 68

  Fly    49 NLAGYLEIIQSQNATSTDIIVFPESTLNSAGST--------TFVPNPE-DQINPCLSDPNATYYE 104
            ||..|.:.:.:.......||||||..::....|        .|:|:|: .:.|||| :|:.....
Human    69 NLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRWNPCL-EPHRFNDT 132

  Fly   105 EFLVTLSCAARNASKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVH 169
            |.|..|||.|.....::|.||..|:.|..  .|.| |..:|...|||||||...|.:|.||||.:
Human   133 EVLQRLSCMAIRGDMFLVANLGTKEPCHS--SDPR-CPKDGRYQFNTNVVFSNNGTLVDRYRKHN 194

  Fly   170 LYGEPKNSTFLP-ELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFL 233
            ||.|......|. :|.||:|.|...||.|.||||||:.||.:::.:..:...|||..|.:|||.|
Human   195 LYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLL 259

  Fly   234 TVNGIFSSKAVQIQLGWSYANNVNLLAAGASDPIVGNSGSGI--------YHGRSGSLRSVMRQE 290
            .        |::||..::.|..:|:|||....|::|.:||||        ||.          .|
Human   260 A--------AIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESFWYHD----------ME 306

  Fly   291 SGERSIYVARVPK------------------------------YRAKRRMK----RDLKRQVATS 321
            :.:..:.:|:|.|                              |..|...:    ...|..|...
Human   307 NPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHCDEATKWNVNAP 371

  Fly   322 SSFNIKRDYLENFTSEELKIDAGKIGNLSQNLCHGGFCCHFDLAWRSLGKPSRNTSHYSYRVGIY 386
            .:|:.:..| :|||   |....||.|.|  ::|..|.||:......:|.|.       .|.:|::
Human   372 PTFHSEMMY-DNFT---LVPVWGKEGYL--HVCSNGLCCYLLYERPTLSKE-------LYALGVF 423

  Fly   387 EGWRNEKRLDVNYIRNCGVFTCSGNSIDDCGQLLPDIQRPLVTFTHVEIRVTYPQSREFLLFPDT 451
            :|.....  ...||:.|.:..|.|...|.|||.:.:...............:|       :||..
Human   424 DGLHTVH--GTYYIQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSY-------IFPLF 479

  Fly   452 LLDNLLPLEPKQFEWSQKRISEESHQVRFALRKSLEVKHLLTFGIYGNYYNNE 504
            |...:....|.|..|      |..|   :.||||.....|:|..:||..|..:
Human   480 LTSGMTLEVPDQLGW------ENDH---YFLRKSRLSSGLVTAALYGRLYERD 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	104/362 (29%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	46/178 (26%)
BTD	NP_001268652.2	biotinidase_like	38..341	CDD:143591	99/324 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157427
Domainoid	1	1.000	106	1.000	Domainoid score	I6567
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37255
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4209
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S7850
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8613
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	O	PTHR10609
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.710