DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32751 and Vnn3

DIOPT Version :9

Sequence 1:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001102606.1	Gene:	Vnn3 / 498992	RGDID:	1560609	Length:	500	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	145/544 - (26%)
Similarity:	215/544 - (39%)	Gaps:	115/544 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FFLFCLALGLMLNLSQQASLFKRDFYTAGVVEFEPSNELS--------DNLAGYLEIIQSQNATS 64
            |.||..|:|.|....  |::::.........|...|||.:        |.|...:::...|.|
  Rat    13 FVLFAQAVGAMDTFI--AAVYEHAVILPNKTESPVSNEEALLLINKNIDILENAIKLAARQGA-- 73

  Fly    65 TDIIVFPESTLNS---AGSTTF-----VPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYI 121
             .|||.||..:..   ...|.:     :|:||....|| .||....:......|||.|:..|.||
  Rat    74 -HIIVTPEDGIYGWIFTRETIYPYLEDIPDPEVNWIPC-RDPKRFGFTPVQERLSCLAKENSIYI 136

  Fly   122 VINLTEKQKCEDIPEDTRP-CASNGLNVFNTNVVFDRQGVVVSRYRKVHLYGEPKNSTFLP---E 182
            |.|:.:|:.|    ..|.| |..:|...:|||||||.:|.:.:||.|.:|: ||:.....|   |
  Rat   137 VANIGDKKPC----NTTDPQCPRDGRYQYNTNVVFDSEGRLTARYHKYNLF-EPEIQFDFPKDSE 196

  Fly   183 LSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTVNGIFSSKAVQIQ 247
            |.||:|.|| .||.|.||||..|.||..::.:..:...:.|..|::.||.|:        ||...
  Rat   197 LVTFDTPFG-KFGVFTCFDIFSYDPAVMVVKDSRVDSVLLPTAWYNTLPLLS--------AVPFH 252

  Fly   248 LGWSYANNVNLLAAGASDPIVGNSGSGIY---------------HGR--SGSLRSVMRQESGERS 295
            ..|:.|..||:|||...:..:..:|||||               :|:  ...|||..||..
  Rat   253 SAWARAMGVNVLAANTHNTRMHMTGSGIYSPDAVRVYYYDMETENGQLLLSELRSRPRQHG---- 313

  Fly   296 IYVARVPKYRAKRRMKRDLKRQVATSSSFNIKRDYLENFTSEELKIDAGKIGNLSQNLCHGGFCC 360
             :.|.|......|.:|.....|.....:.     |.:.|:..:|   .|..||.:  :|....||
  Rat   314 -FPAEVDWSAYARTVKPFSSEQADFQGTI-----YFDEFSFTKL---MGSAGNYT--VCQKDLCC 367

  Fly   361 HFDLAWRSLGKPSRNTSHYSYRVGIYEGWRNEKRLDVNYIRNCGVFTCSGNSIDDCGQLLPDIQR 425
            |...      |.|.:....:|.:|.::|....:  ...|::.|.:..|...::..||:.:..
  Rat   368 HLTY------KMSESRMDEAYVLGAFDGLHTVE--GQYYLQICTLLKCQTTNLRTCGEPVGS--- 421

  Fly   426 PLVTFTHVEIRVTYPQSREFLL---------FPDTLLD-NLLPLEPKQFEWSQKRISEESHQVRF 480
               .||..|         ||.|         ||..:|. :.|.||         |..|.|...|.
  Rat   422 ---AFTKFE---------EFSLSGTFGTKYVFPQIVLSGSQLALE---------RYYEVSRDGRL 465

  Fly   481 ALRKSLEVKHLLTFGIYGNYYNNE 504
            ..|....:. :|...:||..:..:
  Rat   466 RSRGGAPLP-VLVMALYGRVFERD 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	98/332 (30%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	40/188 (21%)
Vnn3	NP_001102606.1	biotinidase_like	26..310	CDD:143591	92/303 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351402
Domainoid	1	1.000	87	1.000	Domainoid score	I7801
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9093
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.660