DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32751 and vnn2

DIOPT Version :9

Sequence 1:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001011263.1	Gene:	vnn2 / 496713	XenbaseID:	XB-GENE-5471072	Length:	501	Species:	Xenopus tropicalis

Alignment Length:	546	Identity:	145/546 - (26%)
Similarity:	221/546 - (40%)	Gaps:	116/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FCLALGLMLNLSQQASLFKRDFYTAGVVEFE---PSN-----------ELSDNLAGYLE-IIQSQ 60
            |...|.::||..|..:|   |.:.|...|..   |.|           ||.:.....|| .|:|.
Frog     4 FSFLLLMLLNADQSRAL---DKFIAATYEHAVILPENTLTPVTEEKALELMNRNIDILEKAIKSA 65

  Fly    61 NATSTDIIVFPESTLNS---AGSTTF-----VPNPEDQINPCLSDPNATYYEEFLVTLSCAARNA 117
            ......|||.||..:..   ...|.:     :|:||....|| |||...........|||.|:|.
Frog    66 ATQGAHIIVTPEDGIYGWIFTRETIYPYLEDIPDPEVHWIPC-SDPERFGRAPVQTRLSCIAKNN 129

  Fly   118 SKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLY-GEPK-NSTFL 180
            |.|:|.|:.:|:.|.   ..|..|..:|...:||.||:|..|.:|:||.|.:|: ||.: |....
Frog   130 SIYVVANIGDKKPCN---ISTVGCPEDGHYHYNTAVVYDSDGKLVARYHKYNLFLGETQFNVPPE 191

  Fly   181 PELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTVNGIFSSKAVQ 245
            ||:.||||.|| .||.|||||||||.||..|:|:..:...::|..|.:.||.||        |::
Frog   192 PEMVTFETPFG-KFGIFICFDILFYKPAAALVVDHQVDTVLFPTAWMNVLPHLT--------AIE 247

  Fly   246 IQLGWSYANNVNLLAAGASDPIVGNSGSGIYHGRS-GSLRSVMRQESGER--------------- 294
            ....|:....||||::...:..:..:||||:...: |.....|..|.|..
Frog   248 FHSAWAMGMGVNLLSSNTHNTSMRMTGSGIFSPETLGPYNYNMDTEHGHLILSELSAHPRNSSTF 312

  Fly   295 -----SIYVARVPKYRAKRRMKRDLKRQVATSSSFNIKRDYL--ENFTSEELKIDAGKIGNLSQN 352
                 |:|...:.:|                |...|:.|.:|  :.||..||....|     :..
Frog   313 FIHNWSLYANSIAQY----------------SPGPNVFRGHLFSDEFTFTELTEPQG-----NYT 356

  Fly   353 LCHGGFCCHFDLAWRSLGKPSRNTSHYSYRVGIYEGWRNEKRLDVNYIRNCGVFTCSGNSIDDCG 417
            ||....|||  |.:..:.|.:...    |.:|:::|....:  ...|::.|.:..|....|..||
Frog   357 LCQKNLCCH--LTYTGMEKITDEV----YVLGVFDGLHEIE--GQYYLQICTLLKCLNTDIKSCG 413

  Fly   418 QLLPDIQRPLVTFTHVEIRVTYPQSREFLLFPDTLLDNLLPLEPKQFEWSQKRISEESHQV---- 478
            :   .::.....|....:...:..|   .:||:.||:.:             .::....||
Frog   414 E---PVETASTKFKSFSLSGNFSTS---FVFPEVLLNKV-------------HLATGMFQVLPDG 459

  Fly   479 RFALRKSLEVKHLLTFGIYGNYYNNE 504
            |.....|:..|.||:..::|.:|:.:
Frog   460 RLTSGDSISQKPLLSATLFGRWYDKD 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	100/341 (29%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	39/184 (21%)
vnn2	NP_001011263.1	biotinidase_like	23..324	CDD:143591	97/313 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7475
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4227
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9511
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970