DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Moe and ezr

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001025629.1	Gene:	ezr / 595017	XenbaseID:	XB-GENE-484766	Length:	582	Species:	Xenopus tropicalis

Alignment Length:	644	Identity:	342/644 - (53%)
Similarity:	443/644 - (68%)	Gaps:	80/644 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KTLNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPES 86
            |.:||||||||||||||||.:||||||||||:||:||||||:||||..|:||..||:||.||
Frog     3 KPVNVRVTTMDAELEFAIQPSTTGKQLFDQVIKTVGLREVWYFGLQCIDNKGYLTWLKLDKK--- 64

  Fly    87 PAIKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFR 151
                                                              |..|:|||||||||:
Frog    65 --------------------------------------------------VSAQEVKKENPLQFK 79

  Fly   152 FRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTA 216
            ||||||||||:|||||:||.:||:||||.|||:||:||||||:||||||||||:.||::|.|..:
Frog    80 FRAKFYPEDVSEELIQEITQKLFFLQVKEAILSDEVYCPPETAVLLASYAVQAKFGDYSKETIKS 144

  Fly   217 GFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIR 281
            |:|.::|||||||:|||.:|:|:||:.|..|..|||.||:||||:|||||||||||||:|||||:
Frog   145 GYLTSERLLPQRVLDQHNLSRDQWEERIEVWHSEHRGMLKEDAMLEYLKIAQDLEMYGINYFEIK 209

  Fly   282 NKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRV 346
            ||||:|||||||||||||||.:|:|||||||||||||||||::|||:|||||||||||:|:|||:
Frog   210 NKKGSDLWLGVDALGLNIYEHNDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRL 274

  Fly   347 RINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARERAEKKQQE 411
            |||||||.||||||||||||||||||:||||||||:|||..||.||::|       |:.:||::.
Frog   275 RINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAKEEKLQKQLERQQL-------EQEKKKREA 332

  Fly   412 YEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQL-KQLQAAKDELELRQKELQAMLQRLEEAKNME 475
            .|...:||.::.|.....|.|.::..:|.|.:| :|:|.|| |||..::..|...:|| ||:.:.
Frog   333 IEREREQMIKEKEELMFRLHEYEEQSKRAERELSEQIQRAK-ELEEERRRAQYEAERL-EAERIS 395

  Fly   476 AVE-KLKLEEEIMAKQMEVQRIQDEVNAKD------EETKRLQDEVEDARRKQVIAAEAAAALL- 532
            |:. |.:||.:.:|:....:::..|::...      ||.:|:::  ::|...|:.|.||...||
Frog   396 ALRAKEELERQAIAQTKSQEQLASELSEYTARISLLEEARRVKE--DEASEWQMRAQEAQTDLLR 458

  Fly   533 ------AASTTPQHHHVAEDENENEEELTNGDAGGDVSRDLDTDEHIKD-PIEDRRTLAERNERL 590
                  ...|||........|.....|..:|......|.:|.:.:.::| .::.|.|.||:|||:
Frog   459 TREELHMVMTTPPPPPPPVYEPYRVHEPDDGLEHTSYSAELSSVDFLEDNKMQTRMTEAEKNERV 523

  Fly   591 HDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFENM 649
            ..||.||..:|:|:|||||:|.||.:|.|||:.|||||||||:||:||||:|:|:||.|
Frog   524 QRQLMALTSELSQARDETKKTHNDILHTENVKSGRDKYKTLRQIRQGNTKQRIDEFEAM 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	146/251 (58%)
		FERM_N	28..83	CDD:286467	42/54 (78%)
		FERM_M	163..278	CDD:278785	79/114 (69%)
		FERM_C_ERM	272..368	CDD:270015	82/95 (86%)
		GBP_C	<375..497	CDD:303769	44/123 (36%)
		ERM	403..649	CDD:279153	93/261 (36%)
		coiled coil	464..477	CDD:293879	4/12 (33%)
		coiled coil	486..497	CDD:293879	1/10 (10%)
ezr	NP_001025629.1	B41	7..206	CDD:214604	146/251 (58%)
		FERM_C_ERM	200..296	CDD:270015	82/95 (86%)
		ERM	338..582	CDD:366293	89/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3201
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	687	1.000	Inparanoid score	I688
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281811at33208
OrthoFinder	1	1.000	-	-		FOG0001629
OrthoInspector	1	1.000	-	-		otm48861
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4666
SonicParanoid	1	1.000	-	-		X1031
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090