DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Moe and INAVA

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_060735.4	Gene:	INAVA / 55765	HGNCID:	25599	Length:	663	Species:	Homo sapiens

Alignment Length:	170	Identity:	44/170 - (25%)
Similarity:	72/170 - (42%)	Gaps:	36/170 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 KKQQEYEDRLKQMQEDMER---SQRDL---LEAQDMIRRLEEQLK---QLQAA----------KD 452
            |:|:..|.||:...|::.|   .:.:|   |.|:..::..|:..|   ::.||          :|
Human   121 KQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWALHRED 185

  Fly   453 ELELRQKELQAMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQD----E 513
            .|...:::|...||..|.|:      :|.|||. :::|...||....:    :|.|:||:    .
Human   186 PLSSLERQLALQLQITEAAR------RLCLEEN-LSRQARRQRKHSML----QEEKKLQELQRCL 239

  Fly   514 VEDARRKQVIAAEAAAALLAASTTPQHHHVAEDENENEEE 553
            ||  ||:......|||..|....:........|....|||
Human   240 VE--RRRNSEPPPAAALPLGRELSASDDSSLSDGLLLEEE 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604
		FERM_N	28..83	CDD:286467
		FERM_M	163..278	CDD:278785
		FERM_C_ERM	272..368	CDD:270015
		GBP_C	<375..497	CDD:303769	28/108 (26%)
		ERM	403..649	CDD:279153	44/170 (26%)
		coiled coil	464..477	CDD:293879	4/12 (33%)
		coiled coil	486..497	CDD:293879	3/10 (30%)
INAVA	NP_060735.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		DUF3338	87..215	CDD:314652	25/100 (25%)
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000269\|PubMed:28436939	164..170		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..362		10/36 (28%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000269\|PubMed:28436939	332..338
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..425
		Nuclear localization signal (NLS) 3. /evidence=ECO:0000269\|PubMed:28436939	422..428
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900