Protein Alignment Moe and FRMD4A

DIOPT Version :10

• Sequence 1: NP_727290.1
• Gene: Moe / 31816
• FlyBaseID: FBgn0011661
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001305266.1
• Gene: FRMD4A / 55691
• HGNCID: 25491
• Length: 1072
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 129/600 - (21%)
• Similarity: 239/600 - (39%)
• Gaps: 152/600 - (25%)

  Fly    32 DAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPESPAIKTIKYLK 96
            |.:||..:|.....|:|.|.|.....|:|..:||:.:||..|...|::|.::
Human    62 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRR------------- 113

  Fly    97 RVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDV-KKENPLQFRFRAKFYPED 160
                                                    |:..|. ||..|:...|..:||.|.
Human   114 ----------------------------------------VLEHDFPKKSGPVVLYFCVRFYIES 138

  Fly   161 VAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGFLANDRLL 225
            :: .|..:.|:.||:|..|:.|..:.|....|....||||.:|...||.:........|.....|
Human   139 IS-YLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPAL 202

  Fly   226 PQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTDLWL 290
            |.:.:.:|. |....|..::..:::.....|..|::.|:.|.:.|..|||:|:.:::|:|...||
Human   203 PTQALKEHP-SLAYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWL 266

  Fly   291 GVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKK--------------APDFMF 341
            |:...|:..|:..|::.|:..|.|.::.|:.|.||||.::..|.:              |....:
Human   267 GLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWY 331

  Fly   342 FAPRVRINKRILALCMGNHELYMRRRKPDT------------IDVQQ------------------ 376
            ..|  .:.|.|.|:.:..|:.|:.|::..:            ||:.:
Human   332 ACP--ALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKI 394

  Fly   377 -------MKAQAREEKNAKQQEREKLQLALAARERAEKKQQEYEDRLKQMQEDMER---SQRDLL 431
                   :.:...:|.::.|..::.:..||.:|      |:..|:.|:|..|::::   .:.:|.
Human   395 ISGSSGSLLSSGSQESDSSQSAKKDMLAALKSR------QEALEETLRQRLEELKKLCLREAELT 453

  Fly   432 ------------EAQDMIRRLEEQLKQLQAAKDELELRQKELQAMLQRLE-----EAKNMEAVEK 479
                        |...::||......:|    ||.::..|..:|.|:|||     :::..||..:
Human   454 GKLPVEYPLDPGEEPPIVRRRIGTAFKL----DEQKILPKGEEAELERLEREFAIQSQITEAARR 514

  Fly   480 LKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAALLAASTTPQHHHVA 544
            |..:..: :|:::.||....:||    .|:|| |:|:|..:..|.:       ....|.:...:.
Human   515 LASDPNV-SKKLKKQRKTSYLNA----LKKLQ-EIENAINENRIKS-------GKKPTQRASLII 566

  Fly   545 EDENENEEELTNGDA 559
            :|.|...|:.:..||
Human   567 DDGNIASEDSSLSDA 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	56/246 (23%)
		FERM_C_ERM	272..368	CDD:270015	30/109 (28%)
		ERM_helical	402..521	CDD:466641	33/138 (24%)
		ERM_C	573..649	CDD:459932
FRMD4A	NP_001305266.1	FERM_F1_FRMD4B	51..139	CDD:340720	26/129 (20%)
		B41	54..254	CDD:214604	56/246 (23%)
		FERM_C_FRMD4A_FRMD4B	250..360	CDD:270012	29/111 (26%)
		CUPID	389..524	CDD:463360	26/145 (18%)