Protein Alignment Moe and Ezr

DIOPT Version :10

• Sequence 1: NP_727290.1
• Gene: Moe / 31816
• FlyBaseID: FBgn0011661
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_062230.1
• Gene: Ezr / 54319
• RGDID: 621161
• Length: 586
• Species: Rattus norvegicus
• Alignment Length: 651
• Identity: 341/651 - (52%)
• Similarity: 436/651 - (66%)
• Gaps: 90/651 - (13%)

  Fly    22 KTLNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPES 86
            |.:||||||||||||||||..||||||||||||||||||||:|||||.|:||..||:||.||
  Rat     3 KPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKK--- 64

  Fly    87 PAIKTIKYLKRVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFR 151
                                                              |..|:|:||||:||:
  Rat    65 --------------------------------------------------VSAQEVRKENPVQFK 79

  Fly   152 FRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTA 216
            |||||||||||:|||||||.:||:||||..||:|||||||||:|||.||||||:.||:||..|.:
  Rat    80 FRAKFYPEDVADELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEMHKS 144

  Fly   217 GFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIR 281
            |:|:::||:||||:||||:|:|:||..|..|..|||.||::.||:|||||||||||||:|||||:
  Rat   145 GYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIK 209

  Fly   282 NKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRV 346
            ||||||||||||||||||||:||:|||||||||||||||||::|||:|||||||||||:|:|||:
  Rat   210 NKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRL 274

  Fly   347 RINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARERAEKKQ-- 409
            |||||||.||||||||||||||||||:||||||||||||:.||.||::|:.....||..|:::
  Rat   275 RINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQ 339

  Fly   410 ------------QEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQA-------AKDELE 455
                        |::|.:.|:.::::.......|:.::..||.:|:.::|:|       ||:|||
  Rat   340 MLREKEELMLRLQDFEQKTKRAEKELSEQIEKALQLEEERRRAQEEAERLEADRMAALRAKEELE 404

  Fly   456 LRQKELQAMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRK 520
             ||.:.|...|....|:..|...|:.|.||..      :|.:|||.......|..||::...:.:
  Rat   405 -RQAQDQIKSQEQLAAELAEYTAKIALLEEAR------RRKEDEVEEWQHRAKEAQDDLVKTKEE 462

  Fly   521 QVIAAEAAAALLAASTTPQHHHVAED-ENENEEELTNGDAGGDVSRDLDTDEHIKDPIEDRR-TL 583
            ..:...|..........|.::||.|. ::|..|.:       ..|.:|.::..:.|..|::| |.
  Rat   463 LHLVMTAPPPPPPPVYEPVNYHVQEGLQDEGAEPM-------GYSAELSSEGILDDRNEEKRITE 520

  Fly   584 AERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFEN 648
            ||:|||:..||..|..:|:|:|||.|.|.||.||.||:|||||||||||:||:||||:|:|:||.
  Rat   521 AEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEA 585

  Fly   649 M 649
            |
  Rat   586 M 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	146/251 (58%)
		FERM_C_ERM	272..368	CDD:270015	84/95 (88%)
		ERM_helical	402..521	CDD:466641	34/139 (24%)
		ERM_C	573..649	CDD:459932	46/76 (61%)
Ezr	NP_062230.1	B41	7..206	CDD:214604	146/251 (58%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000250|UniProtKB:P15311	115..120		4/4 (100%)
		FERM_C_ERM	200..296	CDD:270015	84/95 (88%)
		Interaction with SCYL3. /evidence=ECO:0000250	244..586		156/355 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..338		16/31 (52%)
		ERM_helical	337..456	CDD:466641	31/125 (25%)
		ERM_C	510..586	CDD:459932	46/75 (61%)